CREB Antibody, clone NL904, rabbit monoclonal | EMD Millipore 04-767 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

CREB Antibody, clone NL904, rabbit monoclonal

catalog :

04-767

quantity :

100 μL

clonality :

monoclonal

host :

domestic rabbit

conjugate :

nonconjugated

clone name :

NL904

reactivity :

human, mouse, rat

application :

western blot, immunocytochemistry, immunoprecipitation

citations: 3

Published Application/Species/Sample/Dilution	Reference
western blot; rat; 1:5000; loading ...	Yu X, Curlik D, Oh M, Yin J, Disterhoft J. CREB overexpression in dorsal CA1 ameliorates long-term memory deficits in aged rats. elife. 2017;6: pubmed publisher
western blot; mouse; loading ...; fig 2d	Park J, Kim S, Yoo J, Jang J, Lee A, Oh J, et al. Novel Neuroprotective Effects of Melanin-Concentrating Hormone in Parkinson's Disease. Mol Neurobiol. 2017;54:7706-7721 pubmed publisher
immunocytochemistry; human western blot; human	Trinh A, Kim S, Chang H, Mastrocola A, Tibbetts R. Cyclin-dependent kinase 1-dependent phosphorylation of cAMP response element-binding protein decreases chromatin occupancy. J Biol Chem. 2013;288:23765-75 pubmed publisher

product information

Catalog Number :

04-767

Subcategory :

Epigenetics & Nuclear Function

Product Name :

Anti-CREB Antibody, clone NL904, rabbit monoclonal

Product Type :

Antibodies

Clonality :

Monoclonal Antibody

Gene ID :

P16220

Host Name :

Rabbit

Antigen :

CREB

Clone :

NL904

Conjugate :

Culture Supernatant

Isotype :

IgG

Product Description :

Anti-CREB Antibody, clone NL904, rabbit monoclonal

Cross Reactivity :

Human;Mouse;Rat

Background :

CREB is a beta ZIP transcription factor that activates target genes through cAMP response elements. CREB is able to mediate signals from numerous physiological stimuli, resulting in regulation of a broad array of cellular responses. While CREB is expressed in numerous tissues, it plays a large regulatory role in the nervous system. CREB is believed to play a key role in promoting neuronal survival, precursor proliferation, neurite outgrowth and neuronal differentiation in certain neuronal populations. Additionally, CREB signaling is involved in learning and memory in several organisms. CREB is able to selectively activate numerous downstream genes through interactions with different dimerization partners. CREB is activated by phosphorylation at Ser133 by various signaling pathways including Erk, Ca2+ and stress signaling. Some of the kinases involved in phosphorylating CREB at Ser133 are p90RSK, MSK, CaMKIV and MAPKAPK-2.

Immunogen :

peptide (C-SGAENQQSGDAAVTEAENQQ) corresponding to amino acids 5-24 of human CREB

Specificity :

Recognizes CREB.

Package Size :

100 μL

Uses :

Immunoprecipitation;Western Blotting

Storage :

Stable for 1 year at -20°C from date of receipt. For maximum recovery of product, centrifuge the vial prior to removing the cap. It is suggested product be sub-aliquoted to avoid repeated freeze / thaw cycles.