LAP2α Antibody, clone 3A3 | EMD Millipore 04-640 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

LAP2α Antibody, clone 3A3

catalog :

04-640

quantity :

100 µg

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

3A3

The same clone is also sold as:

Cell Signaling Technology: 5369
Santa Cruz Biotechnology: sc-81610
Invitrogen: MA5-36300

reactivity :

human

application :

western blot, immunocytochemistry

citations: 2

Published Application/Species/Sample/Dilution	Reference
immunocytochemistry; human western blot; human	Crabbe L, Cesare A, Kasuboski J, Fitzpatrick J, Karlseder J. Human telomeres are tethered to the nuclear envelope during postmitotic nuclear assembly. Cell Rep. 2012;2:1521-9 pubmed publisher
	Gierut J, Zheng Y, Bie W, Carroll R, Ball Kell S, Haegebarth A, et al. Disruption of the mouse protein tyrosine kinase 6 gene prevents STAT3 activation and confers resistance to azoxymethane. Gastroenterology. 2011;141:1371-80, 1380.e1-2 pubmed publisher

product information

Catalog Number :

04-640

Subcategory :

Cell Structure

Product Name :

Anti-LAP2α Antibody, clone 3A3

Product Type :

Antibodies

Clonality :

Monoclonal Antibody

Gene ID :

P42166

Host Name :

Mouse

Antigen :

LAP2α

Clone :

clone 3A3

Conjugate :

Purified

Isotype :

IgG1κ

Product Description :

Anti-LAP2α Antibody, clone 3A3

Cross Reactivity :

Human

Background :

The inner membrane of the nuclear envelope is connected to the nuclear lamina. The main components of the nuclear lamina are Type V intermediate filaments called lamins and lamin binding proteins including lamin B receptor, emerin, MANI, LAP1 (3 isoforms), and LAP2 (several isoforms). The lamins are divided into two groups: the constitutively expressed lamin B and the developmentaly regulated lamin A. The best characterized isoforms of lamin binding protein LAP2 are LAP2α and LAP2β. LAP2β is a type II membrane protein in the inner nuclear membrane that binds lamin B and is important to cell viability and controlling nuclear lamina growth. LAP2α has been characterized as a nucleoplasmic protein that interacts with A-type lamins to control gene expression, transcription, and chromatin organization. LAP2 has a unique COOH terminus from the other LAP2 isoforms. The COOH terminus of LAP2 binds Rb (Retinoblastoma) and is thought to play a role in cell cycle progression and differentiation.

Immunogen :

KLH conjugated synthetic peptide to C terminus region of human LAPα. This antibody detects LAP2α regardless of a naturally occurring Arginine to Cysteine mutation at position 690.

Specificity :

Human LAP2α. Does not cross react with mouse or rat LAP2α

Package Size :

100 µg

Uses :

Western Blotting;Immunofluorescence

Storage :

Maintain at 2-8°C in undiluted aliquots for up to 6 months after date of receipt.