PARP-1 (p116/p25) Antibody, rabbit monoclonal | EMD Millipore 04-575 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

PARP-1 (p116/p25) Antibody, rabbit monoclonal

catalog :

04-575

quantity :

100 µL

clonality :

monoclonal

host :

domestic rabbit

conjugate :

nonconjugated

clone name :

Y17

reactivity :

human

application :

western blot, immunoprecipitation

citations: 2

Published Application/Species/Sample/Dilution	Reference
western blot; human; 1:1000	Carmody Soni E, Schlottman S, Erkizan H, Uren A, Toretsky J. Loss of SS18-SSX1 inhibits viability and induces apoptosis in synovial sarcoma. Clin Orthop Relat Res. 2014;472:874-82 pubmed publisher
	Dzinic S, Kaplun A, Li X, Bernardo M, Meng Y, Dean I, et al. Identification of an intrinsic determinant critical for maspin subcellular localization and function. PLoS ONE. 2013;8:e74502 pubmed publisher

product information

Catalog Number :

04-575

Subcategory :

Apoptosis & Cancer

Product Name :

Anti-PARP-1 (p116/p25) Antibody, rabbit monoclonal

Product Type :

Antibodies

Clonality :

Monoclonal Antibody

Gene ID :

P09874

Host Name :

Rabbit

Antigen :

PARP-1 (p116/p25)

Clone :

Y17

Conjugate :

Purified

Product Description :

Anti-PARP-1 (p116/p25) Antibody, rabbit monoclonal

Cross Reactivity :

Human

Background :

Poly (ADP-ribose) polymerase (PARP) is zinc-dependent DNA binding protein that recognizes DNA strand breaks and is presumed to play a role in DNA repair (1). As a marker for apoptosis, PARP is cleaved in vitro by many caspases, and in vivo by Caspase-3 (2,3). Existing as a 116 kDa nuclear protein, PARP is cleaved between amino acids Asp214 and Gly215 to yield two fragments of 29 kDa (C-terminal catalytic domain) and 85 kDa (N-terminal DNA-binding domain) (2,4).

ALT Names :

poly (ADP-ribose) polymerase-1;ARTD1

Immunogen :

A synthetic peptide corresponding to residues before the cleavage site of human PARP-1. The antibody only recognizes full-length form (p116) of PARP-1.

Specificity :

Recognizes Human PARP-1 (p116/p25).

Package Size :

100 µL

Uses :

Immunoprecipitation;Western Blotting

Storage :

Store at -20 °C. Stable for 12 months from date of receipt.