Caspase-8 Antibody, rabbit monoclonal | EMD Millipore 04-573 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

Caspase-8 Antibody, rabbit monoclonal

catalog :

04-573

quantity :

100 µL

clonality :

monoclonal

host :

domestic rabbit

conjugate :

nonconjugated

clone name :

E7

The same clone is also sold as:

Abcam: ab32397

reactivity :

human

application :

western blot, immunoprecipitation, flow cytometry

citations: 1

Reference
Kumar R, Tiwari A, Chaturvedi U, Kumar G, Sahoo A, Rajmani R, et al. Velogenic newcastle disease virus as an oncolytic virotherapeutics: in vitro characterization. Appl Biochem Biotechnol. 2012;167:2005-22 pubmed publisher

product information

Catalog Number :

04-573

Subcategory :

Apoptosis & Cancer

Product Name :

Anti-Caspase-8 Antibody, rabbit monoclonal

Product Type :

Antibodies

Clonality :

Monoclonal Antibody

Gene ID :

Q14790

Host Name :

Rabbit

Antigen :

Caspase-8

Clone :

Conjugate :

Purified

Product Description :

Anti-Caspase-8 Antibody, rabbit monoclonal

Cross Reactivity :

Human;Rat

Background :

Caspase-8 (MACH/FLICE/Mch5) is a member of a family of cysteine-requiring aspartate proteases that participate in the intracellular signaling cascade leading to apoptosis, or programmed cell death (1-4). Caspase-8 is recruited to death-inducing signaling complex (DISC) CD95 (Fas/APO-1) and tumor necrosis factor receptor 1 (TNFR1) and is subsequently activated by proteolytic cleavage into two residues, p10 and p18 (1-4). Active caspase-8, the first in the caspase signaling cascade, signals downstream caspases to eventually induce apoptosis.

Immunogen :

A synthetic peptide corresponding to N-terminal residues of human Caspase-8 subunit p18. The antibody should recognize both pro-form (55kDa) and p18 cleaved-form of Caspase-8.

Specificity :

Recognizes Human, Rat Caspase-8.

Package Size :

100 µL

Uses :

Immunoprecipitation;Western Blotting;Flow Cytometry

Storage :

Store at -20 °C. Stable for 12 months from date of receipt.