Caspase 2 Antibody, rabbit monoclonal | EMD Millipore 04-571 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

Caspase 2 Antibody, rabbit monoclonal

catalog :

04-571

quantity :

100 µL

clonality :

monoclonal

host :

domestic rabbit

conjugate :

nonconjugated

clone name :

Y61

reactivity :

human, mouse

application :

western blot, flow cytometry

product information

Catalog Number :

04-571

Subcategory :

Apoptosis & Cancer

Product Name :

Anti-Caspase 2 Antibody, rabbit monoclonal

Product Type :

Antibodies

Clonality :

Monoclonal Antibody

Gene ID :

P42575

Host Name :

Rabbit

Antigen :

Caspase 2

Clone :

Y61

Conjugate :

Purified

Product Description :

Anti-Caspase 2 Antibody, rabbit monoclonal

Cross Reactivity :

Human;Mouse

Background :

Caspase-2 (Nedd2/ICH-1) is part of a family of aspartate-specific cysteine proteases that participate in programmed cell death, or apoptosis. Caspase-2 is localized to the nucleus, and has been shown to play roles in both positive and negative regulation of apoptosis (1). Upon apoptotic stimulation, pro-caspase-9 is cleaved in a series of steps to produce an 18-kDa large subunit and a 12-kDa small fragment (2). Caspase-2 can be a nuclear initiator caspase, as it has been shown to precede the processing and activation of caspase-8, -9, and -3 (3). Caspase-2 might also act as an effector caspase; in apoptotic pathways resulting from UV-induced DNA damage, processing of caspase-2 occurs downstream of caspase-9 and caspase-3 activation (4).

Immunogen :

A synthetic peptide corresponding to N-terminus of human Caspase-2 p15 subunit. The antibody should recognize both pro-form (~50kDa) and p15 cleaved-form of Caspase-2.

Specificity :

Recognizes Human, Mouse Caspase-2.

Package Size :

100 µL

Uses :

Flow Cytometry;Western Blotting

Storage :

Store at -20 °C. Stable for 12 months from date of receipt.