phospho-p53 (Ser6) Antibody, clone Y179, rabbit monoclonal | EMD Millipore 04-540 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

phospho-p53 (Ser6) Antibody, clone Y179, rabbit monoclonal

catalog :

04-540

quantity :

100 µL

clonality :

monoclonal

host :

domestic rabbit

conjugate :

nonconjugated

clone name :

Y179

reactivity :

human

application :

western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation

citations: 2

Published Application/Species/Sample/Dilution	Reference
western blot; human; fig 6	Stepanenko A, Andreieva S, Korets K, Mykytenko D, Baklaushev V, Huleyuk N, et al. Temozolomide promotes genomic and phenotypic changes in glioblastoma cells. Cancer Cell Int. 2016;16:36 pubmed publisher
	Chellappa K, Jankova L, Schnabl J, Pan S, Brelivet Y, Fung C, et al. Src tyrosine kinase phosphorylation of nuclear receptor HNF4? correlates with isoform-specific loss of HNF4? in human colon cancer. Proc Natl Acad Sci U S A. 2012;109:2302-7 pubmed publisher

product information

Catalog Number :

04-540

Subcategory :

Epigenetics & Nuclear Function

Product Name :

Anti-phospho-p53 (Ser6) Antibody, clone Y179, rabbit monoclonal

Product Type :

Antibodies

Clonality :

Monoclonal Antibody

Gene ID :

P04637

Host Name :

Rabbit

Antigen :

phospho-p53 (Ser6)

Clone :

Y179

Conjugate :

Culture Supernatant

Isotype :

IgG

Product Description :

Anti-phospho-p53 (Ser6) Antibody, clone Y179, rabbit monoclonal

Cross Reactivity :

Human

Background :

The p53 gene is mutated in approximately half of all human cancers. It is involved in the cellular response to cytotoxic stresses, and together with p19ARF, induces expression of p21Cip1, to cause cell cycle arrest. In addition, p53 is able to induce apoptosis, both by transcriptional and non-transcriptional mechanisms. The amino-terminal 83 amino acids of p53 contain the transactivation domain, as well as the region involved in transcription-independent growth suppression. The carboxy-terminal region contains the DNA-binding domain, which is regulated by three phosphorylation events, and potentially by acetylation also.

ALT Names :

Antigen NY-CO-13 ;Phosphoprotein p53 ;Tumor suppressor p53 ;p53 antigen;p53 transformation suppressor;p53 tumor suppressor ;transformation-related protein 53;tumor protein p53

Immunogen :

KLH conjugated linear peptide corresponding to Phospho p53.

Specificity :

This antibody recognizes phospho-p53 (Ser6).

Package Size :

100 µL

Uses :

Western Blotting;Immunocytochemistry;Immunohistochemistry;Immunoprecipitation

Storage :

Stable for 1 year at -20ºC from date of receipt. Handling Recommendations: Upon receipt, and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance. Note: Variability in freezer temperatures below -20°C may cause glycerol containing solutions to become frozen during storage.