Lck/p56 Antibody, clone Y123, rabbit monoclonal | EMD Millipore 04-372 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

Lck/p56 Antibody, clone Y123, rabbit monoclonal

catalog :

04-372

quantity :

100 µL

clonality :

monoclonal

host :

domestic rabbit

conjugate :

nonconjugated

clone name :

Y123

The same clone is also sold as:

Abcam: ab32149

reactivity :

human

application :

western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation, flow cytometry, immunohistochemistry - paraffin section

product information

Catalog Number :

04-372

Subcategory :

Cell Signaling

Product Name :

Anti-Lck/p56 Antibody, clone Y123, rabbit monoclonal

Product Type :

Antibodies

Clonality :

Monoclonal Antibody

Gene ID :

P06239

Host Name :

Rabbit

Antigen :

Lck/p56

Clone :

Y123

Conjugate :

Unpurified

Isotype :

IgG

Product Description :

Anti-Lck/p56 Antibody, clone Y123, rabbit monoclonal

Cross Reactivity :

Human

Background :

The human T-cell or lymphocyte specific gene Lck/p56 is a member of the Src family of non-receptors tyrosine kinase. Mostly expressed in T cells, Lck has been shown to be critical for the normal development of T lymphocytes (1). Additionally, the N-terminal region of the tyrosine kinase Lck interacts with the cytoplasmic domains of CD4 and CD8 (2). Autophosphorylation at Tyr-394 appears to be required for maximum catalytic activity (3) but it can also be suppressed by phosphorylation of the carboxyl-terminal tyrosine Tyr-505 (4).

ALT Names :

lymphocyte-specific protein tyrosine kinase;Leukocyte C-terminal Src kinase;Lymphocyte cell-specific protein-tyrosine kinase;T cell-specific protein-tyrosine kinase;p56(LSTRA) protein-tyrosine kinase;proto-oncogene tyrosine-protein kinase LCK;T-lymphocyte specific protein tyrosine kinase p56lck;tyrosine-protein kinase Lck;Protein YT16;Proto-oncogene Lck

Immunogen :

Synthetic peptide corresponding to residues before the SH3 domain of human Lck/p56.

Specificity :

This antibody does not cross-react with other SRC family members.

Package Size :

100 µL

Uses :

Western Blotting;Immunocytochemistry;Immunoprecipitation;Flow Cytometry;Immunohistochemistry (Paraffin)

Storage :

Stable for 1 year at -20ºC from date of receipt. Handling Recommendations: Upon first thaw, and prior to removing cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20ºC. Avoid freeze/thaw cycles, which may damage IgG and affect product performance. Note: Variability in freezer temperatures below -20°C may cause glycerol containing solutions to become frozen during storage. Note: Variability in freezer temperatures below -20°C may cause glycerol containing solutions to become frozen during storage.