IKK beta Antibody, clone Y466, rabbit monoclonal | EMD Millipore 04-366 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

IKK beta Antibody, clone Y466, rabbit monoclonal

catalog :

04-366

quantity :

100 µL

clonality :

monoclonal

host :

domestic rabbit

conjugate :

nonconjugated

clone name :

Y466

The same clone is also sold as:

Abcam: ab32135

reactivity :

human, mouse

application :

western blot, immunohistochemistry, immunoprecipitation, flow cytometry, immunohistochemistry - paraffin section

citations: 3

Reference
Vistein R, Puthenveedu M. Src regulates sequence-dependent beta-2 adrenergic receptor recycling via cortactin phosphorylation. Traffic. 2014;15:1195-205 pubmed publisher
Hwang Y, Park K, Chung W. Epigallocatechin-3 gallate inhibits cancer invasion by repressing functional invadopodia formation in oral squamous cell carcinoma. Eur J Pharmacol. 2013;715:286-95 pubmed publisher
Koch J, Solis G, Bodrikov V, Michel U, Haralampieva D, Shypitsyna A, et al. Upregulation of reggie-1/flotillin-2 promotes axon regeneration in the rat optic nerve in vivo and neurite growth in vitro. Neurobiol Dis. 2013;51:168-76 pubmed publisher

product information

Catalog Number :

04-366

Subcategory :

Cell Signaling

Product Name :

Anti-IKK beta Antibody, clone Y466, rabbit monoclonal

Product Type :

Antibodies

Clonality :

Monoclonal Antibody

Gene ID :

O14920

Host Name :

Rabbit

Antigen :

IKK beta

Clone :

Y466

Conjugate :

Unpurified

Isotype :

IgG

Product Description :

Anti-IKK beta Antibody, clone Y466, rabbit monoclonal

Cross Reactivity :

Human;Mouse

Background :

IKK-beta (I-Kappa-B kinase-beta) is a member of the IKK complex which is composed of IKK-alpha, IKK-beta, IKK-gamma and IKAP (1-2). Phosphorylation of I-Kappa-B on a serine residue by the IKK complex frees NF-kB from I-Kappa-B and marks it for degradation via ubiquitination. IKK-beta has been shown to activate NF-kB and phosphorylate IKB-alpha and beta (3). Phosphorylation of 2 sites at the activation loop of IKK-beta is essential for activation of IKK by TNF and IL1. Once activated, IKK-beta autophosphorylates which in turn decreases IKK activity and prevents prolonged activation of the inflammatory response (4). Additionally, IKK-beta activity can also be regulated by MEKK-1 (5).

ALT Names :

inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta;Nuclear factor NF-kappa-B inhibitor kinase beta;I-kappa-B kinase 2;I-kappa-B-kinase beta;inhibitor of nuclear factor kappa-B kinase subunit beta

Immunogen :

Synthetic peptide corresponding to the C-terminus of human IKK beta.

Specificity :

This antibody recognizes the C-terminus of IKK beta.

Package Size :

100 µL

Uses :

Western Blotting;Immunoprecipitation;Flow Cytometry;Immunohistochemistry (Paraffin)

Storage :

Stable for 1 year at -20ºC from date of receipt. Handling Recommendations: Upon first thaw, and prior to removing cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20ºC. Avoid freeze/thaw cycles, which may damage IgG and affect product performance. Note: Variability in freezer temperatures below -20°C may cause glycerol containing solutions to become frozen during storage. Note: Variability in freezer temperatures below -20°C may cause glycerol containing solutions to become frozen during storage.