HER4/ErbB4 Antibody, clone E200, rabbit monoclonal | EMD Millipore 04-348 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

HER4/ErbB4 Antibody, clone E200, rabbit monoclonal

catalog :

04-348

quantity :

100 µL

clonality :

monoclonal

host :

domestic rabbit

conjugate :

nonconjugated

clone name :

E200

The same clone is also sold as:

Abcam: ab32375, ab200518

reactivity :

human, mouse

application :

western blot, immunocytochemistry, immunoprecipitation, flow cytometry

citations: 2

Reference
Das P, Thor A, Edgerton S, Barry S, Chen D, Jones F. Reactivation of epigenetically silenced HER4/ERBB4 results in apoptosis of breast tumor cells. Oncogene. 2010;29:5214-9 pubmed publisher
Talio M, Luconi M, Masi A, Fernández L. Solid surface spectroscopic methodology for ultra-trace urinary nickel monitoring in smokers and non-smokers' subjects. J Pharm Biomed Anal. 2010;52:694-700 pubmed publisher

product information

Catalog Number :

04-348

Subcategory :

Cell Signaling

Product Name :

Anti-HER4/ErbB4 Antibody, clone E200, rabbit monoclonal

Product Type :

Antibodies

Clonality :

Monoclonal Antibody

Gene ID :

Q15303

Host Name :

Rabbit

Antigen :

HER4/ErbB4

Clone :

E200

Conjugate :

Unpurified

Isotype :

IgG

Product Description :

Anti-HER4/ErbB4 Antibody, clone E200, rabbit monoclonal

Cross Reactivity :

Human;Mouse;Rat

Background :

HER4 / ErbB4 is a receptor tyrosine kinase that belongs to the human epidermal growth factor receptor (EGFR) family. ErbB4/HER4 is most predominantly expressed in several breast carcinoma cell lines, and in normal skeletal muscle, heart, pituitary, brain, and cerebellum (1). ErbB4/HER4 is activated by neuregulins (NRG), betacellulin (BTC), and heparin-binding EGF-like growth factor (2). Neuregulins regulate the expression of ligand- and voltage-gated channels in neurons and skeletal muscle by the activation of ErbB 1-4. The ErbB4/HER4 receptor is unique among these receptors because its C-terminal tail binds to a protein motif known as the PDZ domain (3).

ALT Names :

v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian);Proto-oncogene-like protein c-ErbB-4;Tyrosine kinase-type cell surface receptor HER4;v-erb-a avian erythroblastic leukemia viral oncogene homolog-like 4;avian erythroblastic leukemia viral (v-erb-b2) oncogene homolog 4;receptor tyrosine-protein kinase erbB-4

Immunogen :

Synthetic peptide corresponding to the C-terminus of human HER4/ErbB4. The antibody does not cross-react with other EGF receptor family members.

Package Size :

100 µL

Uses :

Western Blotting;Immunocytochemistry;Immunoprecipitation;Flow Cytometry

Storage :

Stable for 1 year at -20ºC from date of receipt. Handling Recommendations: Upon first thaw, and prior to removing cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20ºC. Avoid freeze/thaw cycles, which may damage IgG and affect product performance. Note: Variability in freezer temperatures below -20°C may cause glycerol containing solutions to become frozen during storage. Note: Variability in freezer temperatures below -20°C may cause glycerol containing solutions to become frozen during storage.