Lyn Antibody, clone 10A6.2 | EMD Millipore 04-268 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

Lyn Antibody, clone 10A6.2

catalog :

04-268

quantity :

100 µL

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

10A6.2

reactivity :

human, mouse, chicken

application :

western blot, immunocytochemistry

citations: 2

Published Application/Species/Sample/Dilution	Reference
immunocytochemistry; human	Sharma N, Zhu Q, Wani G, He J, Wang Q, Wani A. USP3 counteracts RNF168 via deubiquitinating H2A and ?H2AX at lysine 13 and 15. Cell Cycle. 2014;13:106-14 pubmed publisher
western blot; human; 1:1000	Sutton P, Borgia J, Bonomi P, Plate J. Lyn, a Src family kinase, regulates activation of epidermal growth factor receptors in lung adenocarcinoma cells. Mol Cancer. 2013;12:76 pubmed publisher

product information

Catalog Number :

04-268

Subcategory :

Cell Signaling

Product Name :

Anti-Lyn Antibody, clone 10A6.2

Product Type :

Antibodies

Clonality :

Monoclonal Antibody

Gene ID :

Q6NUK7

Host Name :

Mouse

Antigen :

Lyn

Clone :

10A6.2

Conjugate :

Ascites

Isotype :

IgG1κ

Product Description :

Anti-Lyn Antibody, clone 10A6.2

Cross Reactivity :

Human;Mouse;Rat;Chicken

Background :

Lyn (V-yes-1 Yamaguchi sarcoma viral related oncogene homolog) is a member of the Src family of protein tyrosine kinases and is expressed primarily in hematopoietic cells and neural tissues. Lyn is involved in the regulation of cell activation by undergoing phosphorylation upon activation. Lyn activation triggers downstream signaling pathways that are mediated by Lyn phosphorylation of tyrosine residues of receptor proteins and recruitment and activation of other kinases including Syk, phospholipase Cγ2 (PLCγ2) and phosphatidyl inositol-3 kinase. Lyn also plays an important role in B cells as a key regulator of both positive and negative signals, thus acting to maintain the balance between activation and inhibition. Deregulation of this balance can result in severe pathological consequences such as autoimmune disease.

ALT Names :

v-yes-1 Yamaguchi sarcoma viral related oncogene homolog

Immunogen :

KLH conjugated linear peptide corresponding to the C-terminus of Lyn.

Specificity :

Recognizes the C-terminus of Lyn (V-yes-1 Yamaguchi sarcoma viral related oncogene homolog).

Package Size :

100 µL

Uses :

Western Blotting

Storage :

Stable for 1 year at -20ºC from date of receipt.