p53 (CT) Antibody, clone E47, rabbit monoclonal | EMD Millipore 04-242 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

p53 (CT) Antibody, clone E47, rabbit monoclonal

catalog :

04-242

quantity :

100 μL

clonality :

monoclonal

host :

domestic rabbit

conjugate :

nonconjugated

clone name :

E47

The same clone is also sold as:

Abcam: ab210717, ab32509

reactivity :

human

application :

western blot, immunocytochemistry, immunoprecipitation, flow cytometry

product information

Catalog Number :

04-242

Subcategory :

Epigenetics & Nuclear Function

Product Name :

Anti-p53 (CT) Antibody, clone E47, rabbit monoclonal

Product Type :

Antibodies

Clonality :

Monoclonal Antibody

Gene ID :

P04637

Host Name :

Rabbit

Antigen :

p53 (CT)

Clone :

E47

Conjugate :

Unpurified

Isotype :

IgG

Product Description :

Anti-p53 (CT) Antibody, clone E47, rabbit monoclonal

Cross Reactivity :

Human

Background :

The p53 gene is mutated in approximately half of all human cancers. It is involved in the cellular response to cytotoxic stresses, and together with p19ARF, induces expression of p21Cip1, to cause cell cycle arrest. In addition, p53 is able to induce apoptosis, both by transcriptional and non-transcriptional mechanisms. The amino-terminal 83 amino acids of p53 contain the transactivation domain, as well as the region involved in transcription-independent growth suppression. The carboxy-terminal region contains the DNA-binding domain, which is regulated by three phosphorylation events, and potentially by acetylation also.

ALT Names :

Antigen NY-CO-13;Phosphoprotein p53;Tumor suppressor p53;p53 antigen;p53 transformation suppressor;p53 tumor suppressor ;transformation-related protein 53;tumor protein p53

Immunogen :

KLH conjugated linear peptide corresponding to p53.

Specificity :

This antibody recognizes p53 at the C-terminus.

Package Size :

100 μL

Uses :

Immunoprecipitation;Immunocytochemistry;Flow Cytometry;Western Blotting

Storage :

Stable for 1 year at -20ºC from date of receipt. Handling Recommendations: Upon receipt, and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance. Note: Variability in freezer temperatures below -20°C may cause glycerol containing solutions to become frozen during storage.