p53 Antibody, clone E26, rabbit monoclonal | EMD Millipore 04-241 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

p53 Antibody, clone E26, rabbit monoclonal

catalog :

04-241

quantity :

100 μL

clonality :

monoclonal

host :

domestic rabbit

conjugate :

nonconjugated

clone name :

E26

The same clone is also sold as:

Abcam: ab225531

reactivity :

human

application :

western blot, immunohistochemistry, immunocytochemistry

citations: 4

Reference
Al Dhaheri Y, Eid A, Abuqamar S, Attoub S, Khasawneh M, Aiche G, et al. Mitotic arrest and apoptosis in breast cancer cells induced by Origanum majorana extract: upregulation of TNF-? and downregulation of survivin and mutant p53. PLoS ONE. 2013;8:e56649 pubmed publisher
Al Dhaheri Y, Attoub S, Arafat K, Abuqamar S, Eid A, Al Faresi N, et al. Salinomycin induces apoptosis and senescence in breast cancer: upregulation of p21, downregulation of survivin and histone H3 and H4 hyperacetylation. Biochim Biophys Acta. 2013;1830:3121-35 pubmed publisher
Lu H, Tung W, Yang J, Huang F, Lee C, Huang Y, et al. In vitro suppression of growth of murine WEHI-3 leukemia cells and in vivo promotion of phagocytosis in a leukemia mice model by indole-3-carbinol. J Agric Food Chem. 2012;60:7634-43 pubmed publisher
Yu C, Ko F, Yu C, Lin C, Huang Y, Yang J, et al. Norcantharidin triggers cell death and DNA damage through S-phase arrest and ROS-modulated apoptotic pathways in TSGH 8301 human urinary bladder carcinoma cells. Int J Oncol. 2012;41:1050-60 pubmed publisher

product information

Catalog Number :

04-241

Subcategory :

Epigenetics & Nuclear Function

Product Name :

Anti-p53 Antibody, clone E26, rabbit monoclonal

Product Type :

Antibodies

Clonality :

Monoclonal Antibody

Gene ID :

P04637

Host Name :

Rabbit

Antigen :

p53

Clone :

E26

Conjugate :

Culture Supernatant

Isotype :

IgG

Product Description :

Anti-p53 Antibody, clone E26, rabbit monoclonal

Cross Reactivity :

Human;Rat

Background :

The p53 gene is mutated in approximately half of all human cancers. It is involved in the cellular response to cytotoxic stresses, and together with p19ARF, induces expression of p21Cip1, to cause cell cycle arrest. In addition, p53 is able to induce apoptosis, both by transcriptional and non-transcriptional mechanisms. The amino-terminal 83 amino acids of p53 contain the transactivation domain, as well as the region involved in transcription-independent growth suppression. The carboxy-terminal region contains the DNA-binding domain, which is regulated by three phosphorylation events, and potentially by acetylation.

ALT Names :

Antigen NY-CO-13 ;Phosphoprotein p53 ;Tumor suppressor p53 ;p53 antigen;p53 transformation suppressor;p53 tumor suppressor ;transformation-related protein 53;tumor protein p53

Immunogen :

Synthetic peptide directed against the area C-terminal to the transactivation domain of human p53.

Specificity :

This antibody recognizes p53, internal region.

Package Size :

100 μL

Uses :

Western Blotting;Immunocytochemistry;Immunohistochemistry

Storage :

Stable for 1 year at -20ºC from date of receipt. Handling Recommendations: Upon receipt, and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance. Note: Variability in freezer temperatures below -20°C may cause glycerol containing solutions to become frozen during storage.