HDAC3 Antibody, clone Y415, rabbit monoclonal | EMD Millipore 04-230 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

HDAC3 Antibody, clone Y415, rabbit monoclonal

catalog :

04-230

quantity :

100 μL

clonality :

monoclonal

host :

domestic rabbit

conjugate :

nonconjugated

clone name :

Y415

The same clone is also sold as:

Abcam: ab32369

reactivity :

human, mouse

application :

western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation, immunohistochemistry - paraffin section

citations: 2

Published Application/Species/Sample/Dilution	Reference
western blot; human; tbl s3	Cheng H, Liang Y, Kuo Y, Chuu C, Lin C, Lee M, et al. Identification of thioridazine, an antipsychotic drug, as an antiglioblastoma and anticancer stem cell agent using public gene expression data. Cell Death Dis. 2015;6:e1753 pubmed publisher
	McAdams R, McPherson R, Dabestani N, Gleason C, Juul S. Left ventricular hypertrophy is prevalent in Sprague-Dawley rats. Comp Med. 2010;60:357-63 pubmed

product information

Catalog Number :

04-230

Subcategory :

Epigenetics & Nuclear Function

Product Name :

Anti-HDAC3 Antibody, clone Y415, rabbit monoclonal

Product Type :

Antibodies

Clonality :

Monoclonal Antibody

Gene ID :

O15379

Host Name :

Rabbit

Antigen :

HDAC3

Clone :

Y415

Conjugate :

Culture Supernatant

Isotype :

IgG

Product Description :

Anti-HDAC3 Antibody, clone Y415, rabbit monoclonal

Cross Reactivity :

Human;Mouse;Rat

Background :

Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. Histone Deacetylase 3 (HDAC3) belongs to the histone deacetylase/acuc/apha family. It has histone deacetylase activity and represses transcription when tethered to a promoter. It may participate in the regulation of transcription through its binding with the zinc-finger transcription factor YY1. This protein can also down-regulate p53 function and thus modulate cell growth and apoptosis. HDAC3 is regarded as a potential tumor suppressor gene that also plays critical roles in S phase progression and DNA damage control.

ALT Names :

histone deacetylase 3

Immunogen :

KLH conjugated to a synthetic peptide from the C-terminal region of human Histone Deacetylase 3.

Specificity :

This antibody recognizes Histone Deacetylase 3 at the C-terminus.

Package Size :

100 μL

Uses :

Immunocytochemistry;Immunohistochemistry;Immunohistochemistry (Paraffin);Immunoprecipitation;Western Blotting

Storage :

Stable for 1 year at -20ºC from date of receipt. Handling Recommendations: Upon first thaw, and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance. Note: Variability in freezer temperatures below -20°C may cause glycerol containing solutions to become frozen during storage.