Cyclin B1 (CT) Antibody, clone Y106, rabbit monoclonal | EMD Millipore 04-220 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

Cyclin B1 (CT) Antibody, clone Y106, rabbit monoclonal

catalog :

04-220

quantity :

100 μL

clonality :

monoclonal

host :

domestic rabbit

conjugate :

nonconjugated

clone name :

Y106

The same clone is also sold as:

Abcam: ab32053

reactivity :

human

application :

western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation, flow cytometry, immunohistochemistry - paraffin section

citations: 2

Published Application/Species/Sample/Dilution	Reference
western blot; human; tbl s3	Cheng H, Liang Y, Kuo Y, Chuu C, Lin C, Lee M, et al. Identification of thioridazine, an antipsychotic drug, as an antiglioblastoma and anticancer stem cell agent using public gene expression data. Cell Death Dis. 2015;6:e1753 pubmed publisher
	Chen W, Hong C, Lin Y, Chang W, Huang H, Liao J, et al. Amyloid-beta (A?) D7H mutation increases oligomeric A?42 and alters properties of A?-zinc/copper assemblies. PLoS ONE. 2012;7:e35807 pubmed publisher

product information

Catalog Number :

04-220

Subcategory :

Epigenetics & Nuclear Function

Product Name :

Anti-Cyclin B1 (CT) Antibody, clone Y106, rabbit monoclonal

Product Type :

Antibodies

Clonality :

Monoclonal Antibody

Gene ID :

P14635

Host Name :

Rabbit

Antigen :

Cyclin B1 (CT)

Clone :

Y106

Conjugate :

Culture Supernatant

Isotype :

IgG

Product Description :

Anti-Cyclin B1 (CT) Antibody, clone Y106, rabbit monoclonal

Cross Reactivity :

Human

Background :

Cyclins are, as their name suggests, expressed at specific times during the cell cycle, and play a crucial role in the regulation of the cell cycle. Cyclins associate with cyclin-dependent kinases (cdks), and the association is absolutely required for cdk activity. At the conclusion of the relevant phase of the cell cycle, cyclins are rapidly ubiquitinated and degraded, thus returning cdks to their inactive state. Cyclin A associates with cdk2, and together with cyclin E is involved in the G1/S transition. Cyclin A/cdk2 remains active during S-phase. Cyclin B associates with cdk1/cdc2 to regulate the G2/M boundary. The D-cyclins bind cdk4 and cdk6, and result in Rb phosphorylation. The cyclin D1 gene was found in chronic B cell lymphocytic leukemia, and was designated Bcl-1 in a previously used nomenclature.

ALT Names :

DNA polymerase delta auxiliary protein;proliferating cell nuclear antigen

Immunogen :

Synthetic peptide identical to the C-terminus of human Cyclin B1.

Specificity :

This antibody recognizes Cyclin B1 at the C-Terminus.

Package Size :

100 μL

Uses :

Flow Cytometry;Immunocytochemistry;Immunohistochemistry;Immunohistochemistry (Paraffin);Immunoprecipitation;Western Blotting

Storage :

Stable for 1 year at -20ºC from date of receipt. Handling Recommendations: Upon first thaw, and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance. Note: Variability in freezer temperatures below -20°C may cause glycerol containing solutions to become frozen during storage.