phospho-c-Myc (Thr58/Ser62) Antibody, rabbit monoclonal | EMD Millipore 04-217 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

phospho-c-Myc (Thr58/Ser62) Antibody, rabbit monoclonal

catalog :

04-217

quantity :

100 μL

clonality :

monoclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human, mouse

application :

western blot, immunocytochemistry, immunoprecipitation

citations: 4

Reference
O Brien E, Selfe J, Martins A, Walters Z, Shipley J. The long non-coding RNA MYCNOS-01 regulates MYCN protein levels and affects growth of MYCN-amplified rhabdomyosarcoma and neuroblastoma cells. BMC Cancer. 2018;18:217 pubmed publisher
Frank S, Berger P, Ljungman M, Miranti C. Human prostate luminal cell differentiation requires NOTCH3 induction by p38-MAPK and MYC. J Cell Sci. 2017;130:1952-1964 pubmed publisher
Ischenko I, Zhi J, Hayman M, Petrenko O. KRAS-dependent suppression of MYC enhances the sensitivity of cancer cells to cytotoxic agents. Oncotarget. 2017;8:17995-18009 pubmed publisher
Amatangelo M, Goodyear S, Varma D, Stearns M. c-Myc expression and MEK1-induced Erk2 nuclear localization are required for TGF-beta induced epithelial-mesenchymal transition and invasion in prostate cancer. Carcinogenesis. 2012;33:1965-75 pubmed publisher

product information

Catalog Number :

04-217

Subcategory :

Epigenetics & Nuclear Function

Product Name :

Anti-phospho-c-Myc (Thr58/Ser62) Antibody, rabbit monoclonal

Product Type :

Antibodies

Clonality :

Monoclonal Antibody

Gene ID :

P01106

Host Name :

Rabbit

Antigen :

phospho-c-Myc (Thr58/Ser62)

Conjugate :

Culture Supernatant

Isotype :

IgG

Product Description :

Anti-phospho-c-Myc (Thr58/Ser62) Antibody, rabbit monoclonal

Cross Reactivity :

Human;Mouse

Background :

Myc is a member of the helix-loop-helix-leucine zipper (bHLH-LZ) family of transcription factors, which dimerizes with Max to activate transcription of some genes and repress others. As Max is essential for Myc activity, the availability of Max is a regulatory mechanism for Myc activity, and members of the Mad family of proteins compete with Myc for Max.

ALT Names :

Transcription factor p64;avian myelocytomatosis viral oncogene homolog;myc proto-oncogene protein;v-myc avian myelocytomatosis viral oncogene homolog ;v-myc myelocytomatosis viral oncogene homolog (avian)

Immunogen :

Synthetic peptide corresponding to sequence surrounding and including phosphorylated Thr58 and Ser62 of human c-Myc.

Specificity :

c-Myc when phosphorylated on residues Thr58/Ser62.

Package Size :

100 μL

Uses :

Immunofluorescence;Immunoprecipitation;Western Blotting

Storage :

Stable for 1 year at -20ºC from date of receipt. Handling Recommendations: Upon first thaw, and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance. Note: Variability in freezer temperatures below -20°C may cause glycerol containing solutions to become frozen during storage.