Activation-induced cytidine deaminase (AID) Antibody, clone EK2-5G9 | EMD Millipore 04-1593 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

Activation-induced cytidine deaminase (AID) Antibody, clone EK2-5G9

catalog :

04-1593

quantity :

100 μg

clonality :

monoclonal

host :

rat

conjugate :

nonconjugated

clone name :

EK2-5G9

The same clone is also sold as:

Invitrogen: MA5-16665
Bio-Rad: MCA4756GT

reactivity :

human

application :

western blot, immunohistochemistry

citations: 1

Reference
Koduru S, Wong E, Strowig T, Sundaram R, Zhang L, Strout M, et al. Dendritic cell-mediated activation-induced cytidine deaminase (AID)-dependent induction of genomic instability in human myeloma. Blood. 2012;119:2302-9 pubmed publisher

product information

Catalog Number :

04-1593

Subcategory :

Inflammation & Immunology

Product Name :

Anti-Activation-induced cytidine deaminase (AID) Antibody, clone EK2-5G9

Product Type :

Antibodies

Clonality :

Monoclonal Antibody

Gene ID :

Q9GZX7

Host Name :

Rat

Antigen :

Activation-induced cytidine deaminase (AID)

Clone :

EK2-5G9

Conjugate :

Purified

Isotype :

IgG2bκ

Product Description :

Anti-Activation-induced cytidine deaminase (AID) Antibody, clone EK2-5G9

Cross Reactivity :

Human

Background :

Activation-induced cytidine deaminase (AID) is a 24 kDa, RNA-editing protein that is necessary for the initiation of both somatic hypermutation (SHM) and class switch recombination (CSR) of the Ig gene through the production of U:G mismatches in DNA, and is primarily found in activated B cells. AID expression has also been observed in several varying types of B cell lymphomas such as; Burkitt’s lymphoma, Hodgkin’s lymphoma, hairy cell lymphoma, follicular lymphoma, mantle cell lymphoma, mucosa-associated lymphoid tissue lymphoma, and mediastinal B cell lymphoma. Mutations in AID expression are causal to autosomal recessive hyper-IgM immunodeficiency syndrome type 2 (HIGM2), which is characterized by serum containing IgM but lacking IgG, IgA and IgE, which leads to severe susceptibility to bacterial infections.

ALT Names :

activation-induced cytidine deaminase;integrated into Burkitt's lymphoma cell line Ramos;Cytidine aminohydrolase

Immunogen :

KLH-conjugated linear peptide corresponding to human AID.

Specificity :

This antibody recognizes activation-induced cytidine deaminase (AID).

Package Size :

100 μg

Uses :

Western Blotting;Immunohistochemistry

Storage :

Stable for 1 year at 2-8°C from date of receipt