IL-6R-alpha Antibody, clone 1C2 | EMD Millipore 04-1581 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

IL-6R-alpha Antibody, clone 1C2

catalog :

04-1581

quantity :

100 μg

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

AB42.52.1C5.1C2

reactivity :

human

application :

western blot, neutralization

product information

Catalog Number :

04-1581

Subcategory :

Inflammation & Immunology

Product Name :

Anti-IL-6R-alpha Antibody, clone 1C2

Product Type :

Antibodies

Clonality :

Monoclonal Antibody

Gene ID :

P08887

Host Name :

Mouse

Antigen :

IL-6R-alpha

Clone :

AB42.52.1C5.1C2

Conjugate :

Purified

Isotype :

IgG1κ

Product Description :

Anti-IL-6R-alpha Antibody, clone 1C2

Cross Reactivity :

Human

Background :

The interleukin-6 receptor (IL-6R) is thought to be made up of two subunits: IL-6R-alpha and gp130. IL-6R-alpha is ligand specific while signal transduction is regulated by gp130. IL-6R is commonly membrane bound but can also be found in a soluble form. It has been found to be inactivated by Porphyromonas gingivalis during infection, most possibly by damaging or inactivating the gp130 subunit of the receptor. IL-6R expression has been linked to aggressiveness of papillary thyroid cancers and medullary thyroid cancers and has also been linked to certain osteoarticular diseases. Recent data has found an association between a certain IL-6R polymorphism and susceptibility to respiratory infections.

ALT Names :

interleukin 6 receptor;IL-6R subunit alpha;Membrane glycoprotein 80;CD126 antigen;interleukin-6 receptor subunit alpha;IL-6 receptor subunit alpha;interleukin 6 receptor alpha subunit

Immunogen :

Cohesin-tagged recombinant protein corresponding to human IL-6R-alpha.

Package Size :

100 μg

Uses :

Western Blotting;Neutralizing

Storage :

Stable for 1 year at -20°C from date of receipt. Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.