NSD1 Antibody, clone 1NW-1A10 | EMD Millipore 04-1565 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

NSD1 Antibody, clone 1NW-1A10

catalog :

04-1565

quantity :

100 µL

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

1NW-1A10

reactivity :

human, mouse

application :

western blot, immunohistochemistry, immunocytochemistry, immunohistochemistry - paraffin section

citations: 3

Published Application/Species/Sample/Dilution	Reference
western blot; human; loading ...; fig 1e	Fang D, Gan H, Lee J, Han J, Wang Z, Riester S, et al. The histone H3.3K36M mutation reprograms the epigenome of chondroblastomas. Science. 2016;352:1344-8 pubmed publisher
western blot; mouse; fig s10c	Lu C, Jain S, Hoelper D, Bechet D, Molden R, Ran L, et al. Histone H3K36 mutations promote sarcomagenesis through altered histone methylation landscape. Science. 2016;352:844-9 pubmed publisher
western blot; human	Nakshatri H, Appaiah H, Anjanappa M, Gilley D, Tanaka H, Badve S, et al. NF-ÎºB-dependent and -independent epigenetic modulation using the novel anti-cancer agent DMAPT. Cell Death Dis. 2015;6:e1608 pubmed publisher

product information

Catalog Number :

04-1565

Subcategory :

Epigenetics & Nuclear Function

Product Name :

Anti-NSD1 Antibody, clone 1NW-1A10

Product Type :

Antibodies

Clonality :

Monoclonal Antibody

Gene ID :

O88491

Host Name :

Mouse

Antigen :

NSD1

Conjugate :

Ascites

Isotype :

IgG1κ

Product Description :

Anti-NSD1 Antibody, clone 1NW-1A10

Cross Reactivity :

Rat;Mouse

Background :

NSD1 (also known as KMT3B) is a histone methyltransferase shown to methylate lysine 36 of histone H3 and lysine 20 of histone H4. NSD1 is a described as an intermediary transcription factor and depending on its cellular context, it is able to either negatively or positively influence transcription. Expression of this gene has been described in skeletal muscles, kidneys, adult and fetal brain, thymus and spleen. Heterozygous mutations and deletions of the NSD1 gene are associated with Sotos Syndrome, an autosomal dominant condition characterized by macrocephaly, tall stature, facial elongation, accelerated bone aging, and mental retardation.

ALT Names :

Androgen receptor-associated coregulator 267;Lysine N-methyltransferase 3B;NR-binding SET domain-containing protein;Nuclear receptor-binding SET domain-containing protein 1;Sotos syndrome;nuclear receptor binding SET domain protein 1

Immunogen :

Recombinant protein corresponding to mouse NSD1.

Specificity :

This antibody recognizes NSD1.

Package Size :

100 µL

Uses :

Western Blotting;Immunocytochemistry;Immunofluorescence;Immunohistochemistry (Paraffin)

Storage :

Stable for 1 year at -20°C from date of receipt. Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.