Estrogen Receptor α Antibody, clone F3-A | EMD Millipore 04-1564 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

Estrogen Receptor α Antibody, clone F3-A

catalog :

04-1564

quantity :

100 µL

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

F3-A

reactivity :

human, mouse

application :

western blot, immunocytochemistry

citations: 2

Reference
Poli V, Fagnocchi L, Fasciani A, Cherubini A, Mazzoleni S, Ferrillo S, et al. MYC-driven epigenetic reprogramming favors the onset of tumorigenesis by inducing a stem cell-like state. Nat Commun. 2018;9:1024 pubmed publisher
Zhang Y, Jiang Y, Lian X, Xu S, Wei J, Chu C, et al. Effects of ERÎ±-specific antagonist on mouse preimplantation embryo development and zygotic genome activation. J Steroid Biochem Mol Biol. 2015;145:13-20 pubmed publisher

product information

Catalog Number :

04-1564

Subcategory :

Epigenetics & Nuclear Function

Product Name :

Anti-Estrogen Receptor α Antibody, clone F3-A

Product Type :

Antibodies

Clonality :

Monoclonal Antibody

Gene ID :

P03372

Host Name :

Mouse

Antigen :

Estrogen Receptor α

Conjugate :

Ascites

Isotype :

IgG1κ

Product Description :

Anti-Estrogen Receptor α Antibody, clone F3-A

Cross Reactivity :

Human;Mouse;Rat

Background :

Estrogen Receptor α (ERα) is a 65 kDa nuclear hormone receptor. This steroid hormone receptor is involved in the regulation of eukaryotic gene expression and affects cellular proliferation and differentiation in target tissues. ERα is a ligand-activated transcription factor and upon being bound by a ligand such as estrogen, a conformational change occurs that allows dimerization and binding to an estrogen response element. When bound to DNA, Estrogen Receptor α can positively or negatively regulate gene transcription. Like other steroid hormone receptors, Estrogen Receptors are intracellular proteins. Two ERs are known, ERα, classically known as ER, and ERβ. The Estrogen Receptor is believed to play an important role in the growth and development of a subset of hormone dependent human breast cancers. ERβ is expressed in prostate, ovary, and other reproductive organs. Although its steroid specificity is very similar to that of the ERα, the molecular mechanisms regulating the transcriptional activity of ERβ may be distinct from those regulating ERα.

ALT Names :

Estradiol receptor;Nuclear receptor subfamily 3 group A member 1;estrogen receptor 1;estrogen receptor alpha;estrogen receptor alpha delta 4*,5,6,7*/633 isoform;estrogen receptor alpha delta 6,7 isoform

Immunogen :

Linear peptide corresponding to human Estrogen Receptor α.

Specificity :

This antibody recognizes Estrogen Receptor α.

Package Size :

100 µL

Uses :

Western Blotting;Immunocytochemistry

Storage :

Stable for 1 year at -20°C from date of receipt. Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.