MDM4 Antibody, clone 7A8 | EMD Millipore 04-1556 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

MDM4 Antibody, clone 7A8

catalog :

04-1556

quantity :

100 μg

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

7A8

reactivity :

human, mouse

application :

western blot

product information

Catalog Number :

04-1556

Subcategory :

Apoptosis & Cancer

Product Name :

Anti-MDM4 Antibody, clone 7A8

Product Type :

Antibodies

Clonality :

Monoclonal Antibody

Gene ID :

O35618

Host Name :

Mouse

Antigen :

MDM4

Clone :

7A8

Conjugate :

Purified

Isotype :

IgG2bκ

Product Description :

Anti-MDM4 Antibody, clone 7A8

Cross Reactivity :

Human;Mouse

Background :

MDM4 (sometimes referred to as MDMX) is a member of the MDM family proteins. It is known to inhibit p53 and p73 mediated cell cycle arrest and apoptosis. MDM4 is amplified or overexpressed in 10-20% of tumors and 65% of retinoblastomas. The full-length protein has significant homology to MDM2 and can also bind to and inhibit p53. In both MDM2 and MDM4, this interaction with p53 occurs via a binding domain located in the N-terminal region of the protein. Other similar domains include the C-terminal RING finger motif. Although these proteins share similar domains, MDM2 and MDM4 are non-redundant p53 inhibitors, since normal levels of either protein does not compensate for the loss of the other. Recent evidence suggests complementary activities for these proteins with MDM4 regulating p53 activity, and MDM2 playing a key role in p53 stability.

ALT Names :

Double minute 4 protein;MDM4-related protein 1;Mdm2-like p53-binding protein;Mdm4 p53 binding protein homolog (mouse);Mdm4, transformed 3T3 cell double minute 4, p53 binding protein;Mdm4, transformed 3T3 cell double minute 4, p53 binding protein (mouse);Protein Mdmx;double minute 4, human homolog of;p53-binding protein;mouse double minute 4 homolog;mouse double minute 4, human homolog of;p53-binding protein;p53-binding protein;p53-binding protein Mdm4

Immunogen :

His-tagged recombinant protein corresponding to mouse MDM4.

Specificity :

This antibody recognizes MDM4.

Package Size :

100 μg

Uses :

Western Blotting

Storage :

Stable for 1 year at 2-8°C from date of receipt