SC-35 Antibody, clone 1SC-4F11 | EMD Millipore 04-1550 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

SC-35 Antibody, clone 1SC-4F11

catalog :

04-1550

quantity :

100 µL

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

1SC-4F11

reactivity :

human, mouse

application :

western blot, immunocytochemistry

citations: 4

Published Application/Species/Sample/Dilution	Reference
immunocytochemistry; human	Werwein E, Dzuganova M, Usadel C, Klempnauer K. B-Myb switches from Cyclin/Cdk-dependent to Jnk- and p38 kinase-dependent phosphorylation and associates with SC35 bodies after UV stress. Cell Death Dis. 2013;4:e511 pubmed publisher
	Pangallo J, Kiladjian J, Cassinat B, Renneville A, Taylor J, Polaski J, et al. Rare and private spliceosomal gene mutations drive partial, complete, and dual phenocopies of hotspot alterations. Blood. 2020;135:1032-1043 pubmed publisher
	Rivera Serrano E, Fritch E, Scholl E, Sherry B. A Cytoplasmic RNA Virus Alters the Function of the Cell Splicing Protein SRSF2. J Virol. 2017;91: pubmed publisher
	Hartung A, Swensen J, Uriz I, Lapin M, Kristjansdottir K, Petersen U, et al. The Splicing Efficiency of Activating HRAS Mutations Can Determine Costello Syndrome Phenotype and Frequency in Cancer. PLoS Genet. 2016;12:e1006039 pubmed publisher

product information

Catalog Number :

04-1550

Subcategory :

Epigenetics & Nuclear Function

Product Name :

Anti-SC-35 Antibody, clone 1SC-4F11

Product Type :

Antibodies

Clonality :

Monoclonal Antibody

Gene ID :

Q01130

Host Name :

Mouse

Antigen :

SC-35

Conjugate :

Ascites

Isotype :

IgG1κ

Product Description :

Anti-SC-35 Antibody, clone 1SC-4F11

Cross Reactivity :

Human;Mouse;Rat

Background :

SC-35 is also known as Splicing factor SC35 and Splicing factor, arginine/serine-rich 2. This protein is encoded by the SFRS2 gene and is a member of the splicing factor SR family. SC-35 is involved in pre-mRNA splicing and is found in bodies in the nucleus that are highly enriched in poly(A) RNA. These nuclear bodies are referred to as speckles, SC 35 domains, or splicing factor compartments (SFCs). The purpose of these bodies is still widely disputed. Speckles correspond largely to, if not entirely to, ultra structures called inter-chromatin granule clusters (IGCs). SC3-35 is required for pre-mRNA splicing events and is highly involved in spliceosomal interaction and assembly. SC-35 is necessary for assembly of the ATP-dependent splicing complex. It is also necessary for the ATP-dependent communication between pre-mRNA and U1 and U2 snRNPs.

ALT Names :

Protein PR264;Splicing component, 35 kDa;Splicing factor SC35;splicing factor, arginine/serine-rich 2

Immunogen :

Ovalbumin-conjugated linear peptide corresponding to human SC35.

Specificity :

This antibody recognizes SC35.

Package Size :

100 µL

Uses :

Western Blotting;Immunocytochemistry

Storage :

Stable for 1 year at -20°C from date of receipt. Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.