B7-H3 (CD276) Antibody, clone MJ8 | EMD Millipore 04-1501 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

B7-H3 (CD276) Antibody, clone MJ8

catalog :

04-1501

quantity :

100 μg

clonality :

monoclonal

host :

rat

conjugate :

nonconjugated

clone name :

MJ8

The same clone is also sold as:

Bio-Rad: MCA5646PE, MCA5646GA
LifeSpan Biosciences: LS-C187524

reactivity :

human, mouse

application :

western blot, immunohistochemistry, flow cytometry

product information

Catalog Number :

04-1501

Subcategory :

Inflammation & Immunology

Product Name :

Anti-B7-H3 (CD276) Antibody, clone MJ8

Product Type :

Antibodies

Clonality :

Monoclonal Antibody

Gene ID :

Q8VE98

Host Name :

Rat

Antigen :

B7-H3 (CD276)

Clone :

MJ8

Conjugate :

Purified

Isotype :

IgG2bκ

Product Description :

Anti-B7-H3 (CD276) Antibody, clone MJ8

Cross Reactivity :

Human;Mouse

Background :

B7 homolog 3 (B7-H3 or CD276) is a costimulatory molecule belonging to the B7 family that signals through the CD28 family of molecules, including CD28, CTLA4 and ICOS. B7-H3 may be involved in the regulation of T-cell-mediated immune response and may play a protective role in tumor cells by inhibiting natural-killer mediated cell lysis, as well as a role of marker for detection of neuroblastoma cells. B7-H3 may also play a key role in providing the placenta and fetus with a suitable immunological environment throughout pregnancy. Both isoform 1 and isoform 2 appear to be redundant in their ability to modulate CD4 T-cell responses. Isoform 2 is shown to enhance the induction of cytotoxic T-cells and selectively stimulates interferon gamma production in the presence of T-cell receptor signaling. B7-H3 is ubiquitous but not detectable in peripheral blood lymphocytes or granulocytes, and it is weakly expressed in resting monocytes. B7-H3 is expressed in dendritic cells derived from monocytes, epithelial cells of sinonasal tissue, extravillous trophoblast cells and Hofbauer cells of the first trimester placenta and term placenta.

ALT Names :

B7 homolog 3;CD276 antigen;CD276 molecule;Costimulatory molecule

Immunogen :

Mouse B7-H3 Ig2a FC fusion protein, consisting of the extracellular domain linked to the Fc portion of mouse IgG2a.

Specificity :

This antibody recognizes the extracellular domain of B7-H3 (CD276).

Package Size :

100 μg

Uses :

Western Blotting;Flow Cytometry;Immunohistochemistry

Storage :

Stable for 1 year at 2-8°C from date of receipt