HIRA Antibody, clone WC119 | EMD Millipore 04-1488 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

HIRA Antibody, clone WC119

catalog :

04-1488

quantity :

100 μg

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

WC119

reactivity :

human, mouse

application :

western blot, immunoprecipitation

citations: 6

Published Application/Species/Sample/Dilution	Reference
western blot; mouse	Ivanauskiene K, Delbarre E, McGhie J, Küntziger T, Wong L, Collas P. The PML-associated protein DEK regulates the balance of H3.3 loading on chromatin and is important for telomere integrity. Genome Res. 2014;24:1584-94 pubmed publisher
	Xiong C, Wen Z, Yu J, Chen J, Liu C, Zhang X, et al. UBN1/2 of HIRA complex is responsible for recognition and deposition of H3.3 at cis-regulatory elements of genes in mouse ES cells. BMC Biol. 2018;16:110 pubmed publisher
	Cohen C, Corpet A, Roubille S, Maroui M, Poccardi N, Rousseau A, et al. Promyelocytic leukemia (PML) nuclear bodies (NBs) induce latent/quiescent HSV-1 genomes chromatinization through a PML NB/Histone H3.3/H3.3 Chaperone Axis. PLoS Pathog. 2018;14:e1007313 pubmed publisher
	Rai T, Glass M, Cole J, Rather M, Marsden M, Neilson M, et al. Histone chaperone HIRA deposits histone H3.3 onto foreign viral DNA and contributes to anti-viral intrinsic immunity. Nucleic Acids Res. 2017;45:11673-11683 pubmed publisher
	ElsÃ¤sser S, Noh K, Diaz N, Allis C, Banaszynski L. Histone H3.3 is required for endogenous retroviral element silencing in embryonic stem cells. Nature. 2015;522:240-244 pubmed publisher
	Komatsu T, Nagata K. Replication-uncoupled histone deposition during adenovirus DNA replication. J Virol. 2012;86:6701-11 pubmed publisher

product information

Catalog Number :

04-1488

Subcategory :

Epigenetics & Nuclear Function

Product Name :

Anti-HIRA Antibody, clone WC119

Product Type :

Antibodies

Clonality :

Monoclonal Antibody

Gene ID :

P54198

Host Name :

Mouse

Antigen :

HIRA

Clone :

WC119

Conjugate :

Purified

Isotype :

IgG1κ

Product Description :

Anti-HIRA Antibody, clone WC119

Cross Reactivity :

Mouse;Human

Background :

HIRA (TUP1 like enhancer of split protein 1) is a protein localized primarily in the nucleus. It functions as a histone chaparone to preferentially place histone H3.3 on nucleosome. It is broadly expressed in a variety of tissues and is expressed during embryogenesis. Data suggests HIRA plays a part in mechanisms of transcriptional regulation similar to that played by yeast HIR1 and HIR2 together. The HIRA protein has been shown to interact with HIRIP3, HIRIP5, histones H2B and H4, and PAX3. HIRA may play a part in the etiology of the DiGeorge syndrome (DGS), a developmental disorder. The clinical features of this disease include absence or hypoplasia of the thymus and parathyroid glands, cardiovascular malformations, facial dysplasia, a cleft palate and mental retardation.

ALT Names :

DiGeorge critical region gene 1;HIR (histone cell cycle regulation defective) homolog A (S. cerevisiae);HIR histone cell cycle regulation defective homolog A;HIR histone cell cycle regulation defective homolog A (S. cerevisiae);TUP1-like enhancer of split protein 1

Immunogen :

GST-tagged recombinant protein corresponding to human HIRA.

Specificity :

This antibody recognizes HIRA.

Package Size :

100 μg

Uses :

Western Blotting;Immunoprecipitation

Storage :

Stable for 1 year at 2-8°C from date of receipt