RPA2 p34 Antibody, clone RPA20 1-46 | EMD Millipore 04-1481 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

RPA2 p34 Antibody, clone RPA20 1-46

catalog :

04-1481

quantity :

100 μg

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

RPA20, 1-46

reactivity :

human, mouse

application :

western blot

citations: 2

Published Application/Species/Sample/Dilution	Reference
western blot; human; fig 1	Young L, Marzio A, Pérez Durán P, Reid D, Meredith D, Roberti D, et al. TIMELESS Forms a Complex with PARP1 Distinct from Its Complex with TIPIN and Plays a Role in the DNA Damage Response. Cell Rep. 2015;13:451-459 pubmed publisher
western blot; human; fig 2	Ahn J, Kim S, Na W, Baek S, Kim J, Min K, et al. SERBP1 affects homologous recombination-mediated DNA repair by regulation of CtIP translation during S phase. Nucleic Acids Res. 2015;43:6321-33 pubmed publisher

product information

Catalog Number :

04-1481

Subcategory :

Epigenetics & Nuclear Function

Product Name :

Anti-RPA2 p34 Antibody, clone RPA20 1-46

Product Type :

Antibodies

Clonality :

Monoclonal Antibody

Gene ID :

P15927

Host Name :

Mouse

Antigen :

RPA2 p34

Clone :

RPA20, 1-46

Conjugate :

Purified

Isotype :

IgG1κ

Product Description :

Anti-RPA2 p34 Antibody, clone RPA20 1-46

Cross Reactivity :

Human;Mouse

Background :

RPA is a heterotrimeric protein complex that binds specifically to single-stranded DNA (ssDNA). It is composed of three subunits, RPA1 (70 kDa), RPA2 (32 kDa), and RPA3 (14 kDa), and plays multiple roles in DNA metabolism. RPA is required for DNA replication initiation, as well as replication elongation. At the onset of DNA replication, RPA is loaded onto chromatin after the binding of Cdc45 to origins. RPA is needed for subsequent loading of DNA polymerase and other replication proteins to initiate DNA replication. After DNA replication begins, RPA moves with replication forks, stabilizing ssDNA and assisting in DNA synthesis. In addition to its replication function, RPA is also known to play essential roles in damage repair and recombination.The 32 kDa subunit, is phosphorylated by the cdc2 family of kinases when cells enter S-phase and in response to DNA damage by ATM, ATR, and DNA-PK. Alternate names for RPA32 include replication protein A 32 kDa subunit, RP-A, RF-A, replication factor-A protein 2, p32, p34, RPA2, REPA2, and RPA32.

ALT Names :

RF-A protein 2;RP-A p32;RP-A p34;Replication factor A protein 2;replication protein A2 (32kD);replication protein A2, 32kDa;Replication protein A 32kDa subunit;RF-A, replication factor-A protein 2;p32;p34;RPA2;REPA2;RPA32.

Immunogen :

His-tagged recombinant protein corresponding to human RPA2.

Specificity :

This antibody recognizes RPA2.

Package Size :

100 μg

Uses :

Western Blotting

Storage :

Stable for 1 year at 2-8°C from date of receipt