PD-1 (CD279) Antibody, clone RMP1-30 | EMD Millipore 04-1468 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

PD-1 (CD279) Antibody, clone RMP1-30

catalog :

04-1468

quantity :

100 μg

clonality :

monoclonal

host :

rat

conjugate :

nonconjugated

clone name :

RMP1-30

The same clone is also sold as:

LifeSpan Biosciences: LS-C57984
BioLegend: 109111, 109125, 109113, 109103, 109123, 109104, 109120, 109118, 109105, 109116, 109110, 109101, 109127, 109112, 109119, 109117, 109121, 109106, 109109, 109115
Invitrogen: 62-9981-82, 12-9981-82, 48-9981-80, 46-9981-82, 11-9981-82, 14-9981-85, 13-9981-82, 63-9981-82, 17-9981-80, 48-9981-82, 12-9981-83, 14-9981-82, 46-9981-80, 12-9981-81, 13-9981-85, 11-9981-81, 17-9981-82
OriGene: AM05572PU-N, AM05572PU-L, TA320438
Santa Cruz Biotechnology: sc-56200
Abnova: MAB10962
Bio-Rad: MCA2464, MCA2464GA, MCA2464A488T, MCA2464A647T, MCA2464A647, MCA2464A488

reactivity :

mouse

application :

flow cytometry

product information

Catalog Number :

04-1468

Subcategory :

Inflammation & Immunology

Product Name :

Anti-PD-1 (CD279) Antibody, clone RMP1-30

Product Type :

Antibodies

Clonality :

Monoclonal Antibody

Gene ID :

Q02242

Host Name :

Rat

Antigen :

PD-1 (CD279)

Clone :

RMP1-30

Conjugate :

Purified

Isotype :

IgG2aκ

Product Description :

Anti-PD-1 (CD279) Antibody, clone RMP1-30

Cross Reactivity :

Mouse

Background :

Programmed Death 1 (PD-1, PDCD1 or CD279) is a Type I membrane protein and a member of the extended CD28/CTLA-4 family of T cell regulators. The protein's structure includes an extracellular IgV domain followed by a transmembrane region and an intracellular tail. PD-1 is expressed on the surface of activated T cells, B cells, and macrophages, suggesting that compared to CTLA-4, PD-1 more broadly negatively regulates immune responses. PD-1 may also induce cell death, in association with other factors. Mutations in PDCD1 gene are associated with susceptibility to systemic lupus erythematosus type 2 (SLEB2), a chronic inflammatory disorder of connective tissue. It affects principally the skin, joints, kidneys and serosal membranes. This disease, which is due to PD-1 disfunction, is thought to represent a failure of the regulatory mechanisms of the autoimmune system.

ALT Names :

CD279 antigen;Protein PD-1;programmed cell death 1

Immunogen :

Recombinant protein corresponding to the extracellular domain of mouse PD-1 (CD279).

Specificity :

This antibody recognizes the extracellular domain of PD-1 (CD279).

Package Size :

100 μg

Uses :

Flow Cytometry

Storage :

Stable for 1 year at 2-8°C from date of receipt