SMN Antibody, clone 62E7 | EMD Millipore 04-1466 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

SMN Antibody, clone 62E7

catalog :

04-1466

quantity :

100 μg

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

62E7

reactivity :

human, mouse

application :

western blot, immunocytochemistry, immunoprecipitation

product information

Catalog Number :

04-1466

Subcategory :

Epigenetics & Nuclear Function

Product Name :

Anti-SMN Antibody, clone 62E7

Product Type :

Antibodies

Clonality :

Monoclonal Antibody

Gene ID :

Q16637

Host Name :

Mouse

Antigen :

SMN

Clone :

62E7

Conjugate :

Purified

Isotype :

IgG1κ

Product Description :

Anti-SMN Antibody, clone 62E7

Cross Reactivity :

Human;Mouse;Xenopus

Background :

The survival of motor neurons (SMN) protein is essential for the biogenesis of small nuclear RNA (snRNA)-ribonucleoproteins (snRNPs), the major components of the pre-mRNA splicing machinery. Though it is ubiquitously expressed, SMN deficiency causes the motor neuron degenerative disease spinal muscular atrophy (SMA). SMN deficiency, similar to that which occurs in severe SMA, has unexpected cell type-specific effects on the repertoire of snRNAs and mRNAs. It alters the stoichiometry of snRNAs and causes widespread pre-mRNA splicing defects in numerous transcripts of diverse genes, preferentially those containing a large number of introns, in SMN-deficient mouse tissues. These findings reveal a key role for the SMN complex in RNA metabolism and in splicing regulation and indicate that SMA is a general splicing disease that is not restricted to motor neurons.

ALT Names :

Component of gems 1;gemin 1;spinal muscular atrophy (Werdnig-Hoffmann disease, Kugelberg-Welander disease);survival of motor neuron 1, telomeric

Immunogen :

His-tagged recombinant protein corresponding to human SMN.

Specificity :

Recognizes SMN.

Package Size :

100 μg

Uses :

Western Blotting;Immunocytochemistry;Immunoprecipitation

Storage :

Stable for 1 year at 2-8°C from date of receipt