CD80 (B7-1) Antibody, clone RM80 | EMD Millipore 04-1461 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

CD80 (B7-1) Antibody, clone RM80

catalog :

04-1461

quantity :

100 μg

clonality :

monoclonal

host :

rat

conjugate :

nonconjugated

clone name :

RM80

The same clone is also sold as:

Invitrogen: MA1-81972
OriGene: AM05570PU-T, AM05570FC-T, AM05570PU-L, AM05570FC-N, AM05570PU-N, AM05570RP-N
Bio-Rad: MCA2462GA, MCA2462FT, MCA2462PE, MCA2462, MCA2462T, MCA2462F, MCA2462A488, MCA2462A647T, MCA2462A647
LifeSpan Biosciences: LS-C44885, LS-C57975, LS-C44886

reactivity :

mouse

application :

immunocytochemistry, flow cytometry

product information

Catalog Number :

04-1461

Subcategory :

Inflammation & Immunology

Product Name :

Anti-CD80 (B7-1) Antibody, clone RM80

Product Type :

Antibodies

Clonality :

Monoclonal Antibody

Gene ID :

Q00609

Host Name :

Rat

Antigen :

CD80 (B7-1)

Clone :

RM80

Conjugate :

Purified

Isotype :

IgG2aκ

Product Description :

Anti-CD80 (B7-1) Antibody, clone RM80

Cross Reactivity :

Mouse

Background :

T-lymphocyte activation antigen CD80 (Activation B7-1 antigen or CTLA-4 counter-receptor B7.1) is found on activated B cells and monocytes, and is involved in costimulatory signals necessary for T cell activation and survival. CD80 mainly binds to CD28, and along with CD86, provides the necessary stimuli to prepare T cells against antigens presented by antigen-presenting cells. CD80 and CD86 also bind to CTLA-4, a cell surface molecule expressed on activated T cells. Interactions between CD80 or CD86 with CTLA-4 decrease the response of T cells. Reactive oxygen stimulates dendritic cells to activate other immune cells, resulting in the up-regulated production of CD80. Activation of this pathway leads to increased T cell TNF production. CD80 is expressed on activated B-cells, macrophages and dendritic cells and also interacts with adenovirus subgroup B fiber proteins and acts as a receptor for these viruses.

ALT Names :

Activation B7-1 antigen;B-lymphocyte activation antigen B7;CD80 antigen;CD80 antigen (CD28 antigen ligand 1, B7-1 antigen);CD80 molecule;CTLA-4 counter-receptor B7.1;costimulatory factor CD80;costimulatory molecule variant IgV-CD80

Immunogen :

Mouse CD80 cDNA-transfected P815 cells.

Specificity :

This antibody recognizes CD80 (B7-1).

Package Size :

100 μg

Uses :

Flow Cytometry;Immunocytochemistry

Storage :

Stable for 1 year at 2-8°C from date of receipt