IRF4 Antibody, clone 3E4 | EMD Millipore 04-142 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

IRF4 Antibody, clone 3E4

catalog :

04-142

quantity :

100 μg

clonality :

monoclonal

host :

rat

conjugate :

nonconjugated

clone name :

3E4

The same clone is also sold as:

Santa Cruz Biotechnology: sc-130921
Invitrogen: 11-9858-80, 56-9858-82, 50-9858-82, 56-9858-80, 12-9858-82, 25-9858-82, 48-9858-82, 61-9858-80, 12-9858-80, 46-9858-80, 46-9858-82, 14-9858-80, 11-9858-82, 14-9858-82, 14-9858-95, 61-9858-82, 48-9858-80, 25-9858-80, 14-9858-37

reactivity :

human, mouse

application :

western blot, immunohistochemistry, flow cytometry

product information

Catalog Number :

04-142

Subcategory :

Cell Structure

Product Name :

Anti-IRF4 Antibody, clone 3E4

Product Type :

Antibodies

Clonality :

Monoclonal Antibody

Gene ID :

Q64287

Host Name :

Rat

Antigen :

IRF4

Clone :

3E4

Conjugate :

Purified

Isotype :

IgG1κ

Product Description :

Anti-IRF4 Antibody, clone 3E4

Cross Reactivity :

Human

Background :

Interferon regulatory factor 4, also known as IRF4, belongs to the IRF family. IRF4 encodes a 450 amino acid polypeptide with a predicted molecular weight of 51.6 kDa (Grossman 1996). The IRF4 gene is expressed in the spleen, lymphocytes and melanocytes, and is induced in to T cells after cross linking with the T cell receptor. IRF4 is a transcriptional activator that binds to the interferon stimulated response element (ISRE) of the MHC class I promoter. IRF4 is essential for mature T and B lymphocyte function. IRF4 interacts with MYD88 to prevent the interaction of IRF5, resulting in negative regulation of Toll Like Receptor (TLR) signaling. High levels of IRF4 have been associated with Epstein Barr Virus (EBV) and may be critical to EBV transformation. Further oncogenic potential has been associated with the involvement of IRF4 with hair color and pigmentation of the skin, which may cause multiple myeloma.

ALT Names :

Interferon regulatory factor 4;IRF-4;Lymphocyte-specific interferon regulatory factor;LSIRF;NF-EM5;PU.1 interaction partner;Transcriptional activator PIP

Immunogen :

GST-tagged recombinant protein corresponding to the C-terminus of mouse IRF4.

Package Size :

100 μg

Uses :

Western Blotting;Immunohistochemistry;Flow Cytometry

Storage :

Stable for 1 year at 2-8°C from date of receipt