TAL-1 Antibody, clone BTL73 | EMD Millipore 04-123 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

TAL-1 Antibody, clone BTL73

catalog :

04-123

quantity :

100 µg

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

BTL73

The same clone is also sold as:

OriGene: TA353479L
Active Motif: 61259

reactivity :

human

application :

western blot, immunohistochemistry

citations: 1

Reference
Farrell J, Sherva R, Chen Z, Luo H, Chu B, Ha S, et al. A 3-bp deletion in the HBS1L-MYB intergenic region on chromosome 6q23 is associated with HbF expression. Blood. 2011;117:4935-45 pubmed publisher

product information

Catalog Number :

04-123

Subcategory :

Epigenetics & Nuclear Function

Product Name :

Anti-TAL-1 Antibody, clone BTL73

Product Type :

Antibodies

Clonality :

Monoclonal Antibody

Gene ID :

P17542

Host Name :

Mouse

Antigen :

TAL-1

Clone :

clone BTL73

Conjugate :

Affinity Purified

Isotype :

IgG1κ

Product Description :

Anti-TAL-1 Antibody, clone BTL73

Cross Reactivity :

Human

Background :

TAL-1, also known as SCL (stem cell leukemia), is a serine phosphoprotein and basic-helix-loop-helix transcription factor. TAL-1 is implicated in the genesis of hemopoietic malignancies and is a positive regulator of erythroid differentiation. A nonrandom, site-specific TAL-1 chromosomal translocation is commonly associated with oncogenic transformation in many T-cell acute lymphoblastic leukemias. TAL-1 binds to the LIM domain containing protein Rhombotin 2 (RBTN2), where it forms a complex with GATA1 or GATA 2 that is essential for erythropoiesis.

ALT Names :

SCL;T-cell acute lymphocytic leukemia 1;TCL5;TAL-1;Stem cell protein

Immunogen :

Recombinant GST-TAL1 (K Pulford, et al., 1995, Blood, 85: 675 - 684)

Specificity :

This antibody detects two predominant protein products of the SCL/TAL1 gene in T cell acute lymphoblastic leukemia (T-ALL): a full length PP42-TAL1 (42/44 kDa) and a truncated form PP24-TAL1 (24/26 kDa).

Package Size :

100 µg

Uses :

Western Blotting;Immunohistochemistry

Storage :

Stable for 1 year at 2-8°C from date of receipt. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.