Anti-Integrin alpha4 Antibody, clone EPR1355Y, rabbit monoclonal | EMD Millipore 04-1131 product information

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

Anti-Integrin alpha4 Antibody, clone EPR1355Y, rabbit monoclonal

catalog :

04-1131

quantity :

100 µL

clonality :

monoclonal

host :

rabbit

conjugate :

nonconjugated

clone name :

EPR1355Y

reactivity :

human

application :

western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation, immunohistochemistry - paraffin section

more info or order :

EMD Millipore product webpage

citations: 2

Reference
Conant C, Schwartz M, Ionescu-Zanetti C. Well plate-coupled microfluidic devices designed for facile image-based cell adhesion and transmigration assays. J Biomol Screen. 2010;15:102-6 pubmed publisher
Vincenzi F, Corciulo C, Targa M, Merighi S, Gessi S, Casetta I, et al. Multiple sclerosis lymphocytes upregulate A2A adenosine receptors that are antiinflammatory when stimulated. Eur J Immunol. 2013;43:2206-16 pubmed publisher

product information

Catalog Number :

04-1131

Subcategory :

Cell Structure

Product Name :

Anti-Integrin alpha4 Antibody, clone EPR1355Y, rabbit monoclonal

Product Type :

Antibodies

Clonality :

Monoclonal Antibody

Gene ID :

P13612

Host Name :

Rabbit

Antigen :

Integrin alpha4

Clone :

EPR1355Y

Conjugate :

Culture Supernatant

Isotype :

IgG

Product Description :

Anti-Integrin alpha4 Antibody, clone EPR1355Y, rabbit monoclonal

Cross Reactivity :

Human

Background :

Integrin alpha4 (CD49d, VLA-4) is a member of the integrin superfamily of adhesion receptors. Integrin alpha4 inhibits cytolytic T cell activity, with inhibitory activity directed against the effector T cells rather than their targets. Thus, where other VLA receptors appear to mediate cell--matrix interactions, VLA-4 may have a cell--cell adhesion function. Unlike any other integrin alpha subunit, the intact (150 kDa) alpha 4 subunit of VLA-4 can sometimes be cleaved into two noncovalently associated fragments (80 and 70 kDa) (Teixido, 1992). Integrin alpha4 is involved in embryogenesis, haematopoiesis and immune responses, possibly because alpha4 regulates cellular functions differently from other integrins through its cytoplasmic tail (Liu, 1999).

ALT Names :

269C wild type ;CD49 antigen-like family member D;CD49d antigen ;Integrin alpha-IV ;antigen CD49D, alpha-4 subunit of VLA-4 receptor ;integrin alpha 4;integrin alpha-4 subunit ;integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor);very late activation protein 4 receptor, alpha 4 subunit

Immunogen :

Synthetic peptide corresponding to residues near the C-terminus of human Integrin alpha4.

Specificity :

This antibody recognizes Integrin alpha4.

Package Size :

100 µL

Uses :

Western Blotting;Immunocytochemistry;Immunohistochemistry (Paraffin);Immunoprecipitation

Storage :

Stable for 1 year at -20ºC from date of receipt. Handling Recommendations: Upon receipt, and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance. Note: Variability in freezer temperatures below -20°C may cause glycerol containing solutions to become frozen during storage.

more info or order :

EMD Millipore product webpage