phospho-Jak2 (Tyr1007/Tyr1008) Antibody, clone E132, rabbit monoclonal | EMD Millipore 04-1098 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

phospho-Jak2 (Tyr1007/Tyr1008) Antibody, clone E132, rabbit monoclonal

catalog :

04-1098

quantity :

100 µL

clonality :

monoclonal

host :

domestic rabbit

conjugate :

nonconjugated

antigen modification :

phosphorylated

clone name :

E132

The same clone is also sold as:

Abcam: ab200340, ab32101

reactivity :

human, mouse

application :

western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation, immunohistochemistry - paraffin section

citations: 2

Published Application/Species/Sample/Dilution	Reference
western blot; mouse; fig 4	Cheng F, Lienlaf M, Wang H, Perez Villarroel P, Lee C, Woan K, et al. A novel role for histone deacetylase 6 in the regulation of the tolerogenic STAT3/IL-10 pathway in APCs. J Immunol. 2014;193:2850-62 pubmed publisher
western blot; human	Tao W, Leng X, Chakraborty S, Ma H, Arlinghaus R. c-Abl activates janus kinase 2 in normal hematopoietic cells. J Biol Chem. 2014;289:21463-72 pubmed publisher

product information

Catalog Number :

04-1098

Subcategory :

Cell Signaling

Product Name :

Anti-phospho-Jak2 (Tyr1007/Tyr1008) Antibody, clone E132, rabbit monoclonal

Product Type :

Antibodies

Clonality :

Monoclonal Antibody

Gene ID :

O60674

Host Name :

Rabbit

Antigen :

phospho-Jak2 (Tyr1007/Tyr1008)

Clone :

E132

Conjugate :

Unpurified

Isotype :

IgG

Product Description :

Anti-phospho-Jak2 (Tyr1007/Tyr1008) Antibody, clone E132, rabbit monoclonal

Cross Reactivity :

Human;Mouse;Rat

Background :

JAK2 (Janus Kinase 2) belongs to the emerging family of non-receptor Janus tyrosine kinases, which regulate a spectrum of cellular functions downstream of activated cytokine receptors in the lympho-hematopoietic system. Immunological stimuli, such as interferons and cytokines, induce recruitment of Stat transcription factors to cytokine receptor-associated JAK2. JAK2 then phosphorylates proximal Stat factors, which subsequently dimerize, translocate to the nucleus and bind to CIS elements upstream of target gene promoters to regulate transcription. The canonical JAK/Stat pathway is integral to maintaining a normal immune system by stimulating proliferation, differentiation, survival and host resistance to pathogens. Altering JAK/Stat signaling to reduce cytokine induced pro-inflammatory responses represents an attractive target for anti-inflammatory therapies. Within the JAK2 kinase domain, there is a region that has considerable sequence homology to the regulatory region of the insulin receptor.

ALT Names :

Janus kinase 2;Janus kinase 2 (a protein tyrosine kinase);tyrosine-protein kinase JAK2

Immunogen :

Phospho-synthetic peptide corresponding to residues surrounding Tyr1007 and Tyr1008 of human Jak2.

Specificity :

The antibody only detects Jak2 phosphorylated on Tyr1007 and Tyr1008.

Package Size :

100 µL

Uses :

Western Blotting;Immunohistochemistry (Paraffin);Immunocytochemistry;Immunoprecipitation

Storage :

Stable for 1 year at -20ºC from date of receipt. Handling Recommendations: Upon first thaw, and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance. Note: Variability in freezer temperatures below -20°C may cause glycerol containing solutions to become frozen during storage.