Anti-SynGAP (CT) Antibody, clone EPR2883Y, rabbit monoclonal | EMD Millipore 04-1071 product information

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

Anti-SynGAP (CT) Antibody, clone EPR2883Y, rabbit monoclonal

catalog :

04-1071

quantity :

100 µL

clonality :

monoclonal

host :

rabbit

conjugate :

nonconjugated

clone name :

EPR2883Y

reactivity :

human, mouse, rat

application :

western blot, flow cytometry, other

more info or order :

EMD Millipore product webpage

citations: 2

Published Application/Species/Sample/Dilution	Reference
other; rat; 1:500; fig 3 western blot; rat; 1:2500; fig 1b	Yang Y, Tao-Cheng J, Bayer K, Reese T, Dosemeci A. Camkii-mediated phosphorylation regulates distributions of Syngap-α1 and -α2 at the postsynaptic density. PLoS ONE. 2013;8:e71795 pubmed publisher
	McMahon A, Barnett M, O'Leary T, Stoney P, Collins M, Papadia S, et al. SynGAP isoforms exert opposing effects on synaptic strength. Nat Commun. 2012;3:900 pubmed publisher

product information

Catalog Number :

04-1071

Subcategory :

Neuroscience

Product Name :

Anti-SynGAP (CT) Antibody, clone EPR2883Y, rabbit monoclonal

Product Type :

Antibodies

Clonality :

Monoclonal Antibody

Gene ID :

Q96PV0

Host Name :

Rabbit

Antigen :

SynGAP (CT)

Clone :

EPR2883Y

Conjugate :

Unpurified

Isotype :

IgG

Product Description :

Anti-SynGAP (CT) Antibody, clone EPR2883Y, rabbit monoclonal

Cross Reactivity :

Human;Mouse;Rat

Background :

Silent synapses, or excitatory synapses that lack functional α- amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors (AMPARs), are thought to be critical for regulation of neuronal circuits and synaptic plasticity. SynGAP, an excitatory synapse-specific RasGAP, regulates AMPAR trafficking, silent synapse number, and excitatory synaptic transmission in hippocampal and cortical cultured neurons. Over expression of SynGAP in neurons results in a remarkable depression of AMPAR-mediated miniature excitatory postsynaptic currents, a significant reduction in synaptic AMPAR surface expression, and a decrease in the insertion of AMPARs into the plasma membrane. Synaptic transmission is increased in neurons from SynGAP knockout mice as well as in neuronal cultures treated with SynGAP small interfering RNA.

ALT Names :

Neuronal RasGAP ;Synaptic Ras GTPase-activating protein 1;Synaptic Ras-GAP 1;synaptic Ras GTPase activating protein 1;synaptic Ras GTPase activating protein 1 (homolog of rat);synaptic Ras GTPase activating protein 1 homolog (rat) ;synaptic Ras GTPase activating protein, 135kDa

Immunogen :

Synthetic peptide corresponding to residues on the C-terminus of human SynGAP.

Specificity :

This antibody recognizes SynGAP at and around the C-terminus.

Package Size :

100 µL

Uses :

Western Blotting;Flow Cytometry

Storage :

Stable for 1 year at -20ºC from date of receipt. Handling Recommendations: Upon first thaw, and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance. Note: Variability in freezer temperatures below -20°C may cause glycerol containing solutions to become frozen during storage.

more info or order :

EMD Millipore product webpage