Anti-Notch1 (Cytoplasmic) Antibody, clone EP1238Y, rabbit monoclonal | EMD Millipore 04-1046 product information

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

Anti-Notch1 (Cytoplasmic) Antibody, clone EP1238Y, rabbit monoclonal

catalog :

04-1046

quantity :

100 µL

clonality :

monoclonal

host :

rabbit

conjugate :

nonconjugated

clone name :

EP1238Y

reactivity :

human, mouse

application :

western blot, immunohistochemistry, immunocytochemistry

more info or order :

EMD Millipore product webpage

citations: 5

Published Application/Species/Sample/Dilution	Reference
western blot; mouse; 1:500	Ehret F, Vogler S, Pojar S, Elliott D, Bradke F, Steiner B, et al. Mouse model of CADASIL reveals novel insights into Notch3 function in adult hippocampal neurogenesis. Neurobiol Dis. 2015;75:131-41 pubmed publisher
	Jahnsen E, Trindade A, Zaun H, Lehoux S, Duarte A, Jones E. Notch1 is pan-endothelial at the onset of flow and regulated by flow. PLoS ONE. 2015;10:e0122622 pubmed publisher
	Gupta R, Sharma M, Suri V, Kakkar A, Singh M, Sarkar C. Study of chromosome 9q gain, Notch pathway regulators and Tenascin-C in ependymomas. J Neurooncol. 2014;116:267-74 pubmed publisher
	Hong K, Wu D, Cheng K, Chen L, Hung W. RECK inhibits stemness gene expression and tumorigenicity of gastric cancer cells by suppressing ADAM-mediated Notch1 activation. J Cell Physiol. 2014;229:191-201 pubmed publisher
	Benner E, Luciano D, Jo R, Abdi K, Paez Gonzalez P, Sheng H, et al. Protective astrogenesis from the SVZ niche after injury is controlled by Notch modulator Thbs4. Nature. 2013;497:369-73 pubmed publisher

product information

Catalog Number :

04-1046

Subcategory :

Cell Signaling

Product Name :

Anti-Notch1 (Cytoplasmic) Antibody, clone EP1238Y, rabbit monoclonal

Product Type :

Antibodies

Clonality :

Monoclonal Antibody

Gene ID :

P46531

Host Name :

Rabbit

Antigen :

Notch1 (Cytoplasmic)

Clone :

EP1238Y

Isotype :

IgG

Product Description :

Anti-Notch1 (Cytoplasmic) Antibody, clone EP1238Y, rabbit monoclonal

Cross Reactivity :

Human;Mouse

Background :

Notch is the receptor for Delta and Jagged ligands, which cause proteolysis of notch to liberate the intracellular domain. That domain translocates to the nucleus and initiates transcription events by binding the DNA binding protein CSL. The notch family members are involved in numerous differentiation and cell lineage determination steps.

ALT Names :

Translocation-associated notch protein TAN-1 ;neurogenic locus notch homolog protein 1

Immunogen :

Synthetic peptide corresponding to the cytoplasmic domain of human Notch1

Specificity :

This antibody recognizes the cytoplasmic domain of Notch1

Package Size :

100 µL

Uses :

Western Blotting;Immunocytochemistry;Immunohistochemistry

Storage :

Stable for 1 year at -20ºC from date of receipt. Handling Recommendations: Upon receipt, and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance. Note: Variability in freezer temperatures below -20°C may cause glycerol containing solutions to become frozen during storage.

more info or order :

EMD Millipore product webpage