SGK Antibody, clone Y238, rabbit monoclonal | EMD Millipore 04-1027 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

SGK Antibody, clone Y238, rabbit monoclonal

catalog :

04-1027

quantity :

100 µL

clonality :

monoclonal

host :

domestic rabbit

conjugate :

nonconjugated

clone name :

Y238

The same clone is also sold as:

Abcam: ab32374

reactivity :

human, mouse

application :

western blot, immunohistochemistry, immunoprecipitation, flow cytometry, immunohistochemistry - paraffin section

product information

Catalog Number :

04-1027

Subcategory :

Cell Signaling

Product Name :

Anti-SGK Antibody, clone Y238, rabbit monoclonal

Product Type :

Antibodies

Clonality :

Monoclonal Antibody

Gene ID :

O00141

Host Name :

Rabbit

Antigen :

SGK

Clone :

Y238

Conjugate :

Unpurified

Isotype :

IgG

Product Description :

Anti-SGK Antibody, clone Y238, rabbit monoclonal

Cross Reactivity :

Human;Rat;Mouse

Background :

Serum and glucocorticoid-regulated kinase (SGK-1) is a 50 kDa Serine/Threonine kinase that plays a role in the regulation of epithelial Na+ transport. Two additional SGK isoforms have been identified (SGK2 and SGK3). SGK is regulated by phosphorylation at Thr256 and Ser422 by the phosphatidyl-dependent protein kinase -1 (PDK1) and PDK-2 respectively. Nedd4-2 regulates SGK activity by catalyzing its ubiquination and degradation. SGK also regulates the binding of Nedd4-2 to the epithelial Na+ channel (ENaC) protein by phosphorylating Nedd4-2 which helps increase Na+ transport. While environmental stresses increases its expression, SGK is known to play a role in promoting cell survival, proliferation and differentiation.

ALT Names :

Serum/glucocorticoid-regulated kinase 1;serine/threonine protein kinase SGK ;serum/glucocorticoid regulated kinase ;serum/glucocorticoid regulated kinase 1

Immunogen :

Synthetic peptide corresponding to residues of human SGK.

Specificity :

This antibody recognizes SGK.

Package Size :

100 µL

Uses :

Western Blotting;Immunohistochemistry (Paraffin);Immunoprecipitation;Flow Cytometry

Storage :

Stable for 1 year at -20ºC from date of receipt. Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance. Note: Variability in freezer temperatures below -20°C may cause glycerol containing solutions to become frozen during storage.