MBNL Antibody, clone 3A4 | EMD Millipore 04-048 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

MBNL Antibody, clone 3A4

catalog :

04-048

quantity :

100 µL

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

3A4

reactivity :

human

application :

western blot

product information

Catalog Number :

04-048

Subcategory :

Epigenetics & Nuclear Function

Product Name :

Anti-MBNL Antibody, clone 3A4

Product Type :

Antibodies

Clonality :

Monoclonal Antibody

Gene ID :

Q9NR56

Host Name :

Mouse

Antigen :

MBNL

Clone :

clone 3A4

Conjugate :

Ascites

Isotype :

IgG1

Product Description :

Anti-MBNL Antibody, clone 3A4

Cross Reactivity :

Human

Background :

Myotonic dystrophy (DM1) is a neuromuscular disorder associated with repeated CTG triplets in the 3'-untranslated region of the DMPK gene. It is hypothesized that the CUG repeats in the mRNA form hairpins that sequester nuclear factors required for proper muscle development and maintenance. MBNL (muscleblind-like protein 1) is an RNA splicing factor that binds to the CUG repeats and is enriched at these mutant RNA foci. MBNL-deficient mice are often used as a model for myotonic muscular dystrophy and siRNA downregulation of MBNL in normal myoblasts results in abnormal insulin receptor splicing.

ALT Names :

Muscleblind-like protein 1 ;muscleblind-like (Drosophila);Triplet-expansion RNA-binding protein ;DKFZp686P06174 ;KIAA0428;EXP35;EXP42;EXP40

Immunogen :

Recombinant MBNL-1 41 kDa isoform amino acids 116-182

Specificity :

Antibody recognizes MBNL-1

Package Size :

100 µL

Uses :

Western Blotting

Storage :

Stable for 1 year at 2-8°C from date of receipt. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.