RalB Antibody, clone 25 | EMD Millipore 04-037 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

RalB Antibody, clone 25

catalog :

04-037

quantity :

100 μg

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

reactivity :

human, mouse

application :

western blot

citations: 10

Published Application/Species/Sample/Dilution	Reference
western blot; human; loading ...; fig s5a	Johansson J, Nászai M, Hodder M, Pickering K, Miller B, Ridgway R, et al. RAL GTPases Drive Intestinal Stem Cell Function and Regeneration through Internalization of WNT Signalosomes. Cell Stem Cell. 2019;24:592-607.e7 pubmed publisher
western blot; mouse; fig s1	Hyenne V, Apaydin A, Rodriguez D, Spiegelhalter C, Hoff Yoessle S, Diem M, et al. RAL-1 controls multivesicular body biogenesis and exosome secretion. J Cell Biol. 2015;211:27-37 pubmed publisher
western blot; mouse	Peschard P, McCarthy A, Leblanc Dominguez V, Yeo M, Guichard S, Stamp G, et al. Genetic deletion of RALA and RALB small GTPases reveals redundant functions in development and tumorigenesis. Curr Biol. 2012;22:2063-8 pubmed publisher
	Han X, Cheng D, Song F, Zeng T, An L, Xie K. Decelerated transport and its mechanism of 2,5-hexanedione on middle-molecular-weight neurofilament in rat dorsal root ganglia cells. Neuroscience. 2014;269:192-8 pubmed publisher
	Song F, Zou C, Han X, Zeng T, Zhang C, Xie K. Reduction of retrograde axonal transport associated-proteins motor proteins, dynein and dynactin in the spinal cord and cerebral cortex of hens by tri-ortho-cresyl phosphate (TOCP). Neurochem Int. 2012;60:99-104 pubmed publisher
	Chidlow G, Daymon M, Wood J, Casson R. Localization of a wide-ranging panel of antigens in the rat retina by immunohistochemistry: comparison of Davidson's solution and formalin as fixatives. J Histochem Cytochem. 2011;59:884-98 pubmed publisher
	Curtiss M, Hostager B, Stepniak E, Singh M, Manhica N, Knisz J, et al. Fyn binds to and phosphorylates T cell immunoglobulin and mucin domain-1 (Tim-1). Mol Immunol. 2011;48:1424-31 pubmed publisher
	Pickard M, Barraud P, Chari D. The transfection of multipotent neural precursor/stem cell transplant populations with magnetic nanoparticles. Biomaterials. 2011;32:2274-84 pubmed publisher
	Sun H, Chen S, Lai M, Chang T, Chen T, Li P, et al. Comparative proteomic profiling of plasma very-low-density and low-density lipoproteins. Clin Chim Acta. 2010;411:336-44 pubmed publisher
	Heo T, Lee S, Bartosch B, Cosset F, Kang C. Hepatitis C virus E2 links soluble human CD81 and SR-B1 protein. Virus Res. 2006;121:58-64 pubmed

product information

Catalog Number :

04-037

Subcategory :

Cell Signaling

Product Name :

Anti-RalB Antibody, clone 25

Product Type :

Antibodies

Clonality :

Monoclonal Antibody

Gene ID :

P11234

Host Name :

Mouse

Antigen :

RalB

Clone :

Clone 25

Conjugate :

Purified

Isotype :

IgG1κ

Product Description :

Anti-RalB Antibody, clone 25

Cross Reactivity :

Human;Mouse;Rat

Background :

RalA and RalB are Ras-family small monomeric GTPases that can be activated through a Ras-dependent mechanism. The two are highly homologous (89%). RalA is required for anchorage-independent proliferation and tumorigeneisis by driving exocyst assembly and polarizatied exocystossis in epithelaial cells (Cascone, 2008). RalB is required for metastatic formation and cell survival by driving exocyst assembly during polarized cell migration (Cascone, 2008). Ral proteins are proximal effectors of oncogenic Ras and their activity is needed to support tumorigenesis in certain cancers. Mutants of Ras that are defective in activating all known Ras effectors except Ral GEF are still able to induce invasive phenotypes in transfected cells, suggesting a role for Ral in these processes

ALT Names :

RAS-like protein B;v-ral simian leukemia viral oncogene homolog B;GTP binding protein;v-ral simian leukemia viral oncogene homolog B (ras related; GTP binding protein)

Immunogen :

Synthetic peptide of the C-terminus of RalB

Specificity :

This antibody is specific for RalB and does not detect RalA.

Package Size :

100 μg

Uses :

Western Blotting

Storage :

Stable for 1 year at 2-8ºC from date of receipt.