SOCS1 Antibody, clone 4H1 (Ascites Free) | EMD Millipore 04-002-C product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

SOCS1 Antibody, clone 4H1 (Ascites Free)

catalog :

04-002-C

quantity :

100 μg

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

4H1

The same clone is also sold as:

LifeSpan Biosciences: LS-C179704, LS-C10263
Invitrogen: 37-4100

reactivity :

human, mouse

application :

western blot, immunoprecipitation

product information

Catalog Number :

04-002-C

Subcategory :

Protein Trafficking

Product Name :

Anti-SOCS1 Antibody, clone 4H1 (Ascites Free)

Product Type :

Antibodies

Clonality :

Monoclonal Antibody

Gene ID :

O35716

Host Name :

Mouse

Antigen :

Socs1

Clone :

4H1

Conjugate :

Purified

Purification Method :

Protein G purified

Isotype :

IgG1κ

Product Description :

Anti-SOCS1 Antibody, clone 4H1 (Ascites Free)

Cross Reactivity :

Human

Background :

SOCS1, also known as Suppressor of cytokine signaling 1, or JAK-binding protein (JAB), STAT-induced STAT inhibitor 1 (SSI-1), or Tec-interacting protein 3 (TIP3), and encoded by the gene SOCS1/CISH1/SSI1/TIP3, is involved in the negative regulation of cytokines signaling that is mediated by several kinases including JAKs, TEC, KIT, GRB2 and VAV kinases. SOCS1 inhibits kinase activity via binding to the target kinase. SOCS1 also appears to be a major regulator of signaling by interleukin 6 (IL6) and leukemia inhibitory factor (LIF), and SOCS1regulates interferon-gamma mediated sensory neuron survival and is a negative regulator in IGF1R signaling pathway. Finally, SOCS1 forms the substrate recognition component of an ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. SOCS1 is localized to the nucleus and cytoplasmic vesicles. SOCS1 is expressed in all tissues with high expression in spleen, small intestine and peripheral blood leukocytes.

ALT Names :

Suppressor of cytokine signaling 1, SOCS-1, JAK-binding protein, JAB, STAT-induced STAT inhibitor 1, SSI-1

Immunogen :

GST-tagged recombinant protein corresponding to mouse SOCS1.

Package Size :

100 μg

Uses :

Western Blotting, Immunoprecipitation

Storage :

Stable for 1 year at 2-8°C from date of receipt