JAK2 Antibody, clone 8E10.2 | EMD Millipore 04-001 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

JAK2 Antibody, clone 8E10.2

catalog :

04-001

quantity :

100 µg

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

8E10.2

reactivity :

human, mouse

application :

western blot, immunohistochemistry, immunohistochemistry - paraffin section

citations: 1

Published Application/Species/Sample/Dilution	Reference
western blot; mouse; fig 4	Guo L, Costanzo Garvey D, Smith D, Zavorka M, Venable Kang M, MacDonald R, et al. Cell non-autonomous regulation of hepatic IGF-1 and neonatal growth by Kinase Suppressor of Ras 2 (KSR2). Sci Rep. 2016;6:32093 pubmed publisher

product information

Catalog Number :

04-001

Subcategory :

Inflammation & Immunology

Product Name :

Anti-JAK2 Antibody, clone 8E10.2

Product Type :

Antibodies

Clonality :

Monoclonal Antibody

Gene ID :

O60674

Host Name :

Mouse

Antigen :

JAK2

Clone :

8E10.2

Conjugate :

Purified

Isotype :

IgG1κ

Product Description :

Anti-JAK2 Antibody, clone 8E10.2

Cross Reactivity :

Human;Mouse;Rat

Background :

JAK2 (Janus Kinase 2) belongs to the emerging family of non-receptor Janus tyrosine kinases, which regulate a spectrum of cellular functions downstream of activated cytokine receptors in the lympho-hematopoietic system. Immunological stimuli, such as interferons and cytokines, induce recruitment of Stat transcription factors to cytokine receptor-associated JAK2. JAK2 then phosphorylates proximal Stat factors, which subsequently dimerizes and translocates to the nucleus and bind to CIS elements upstream of target gene promoters to regulate transcription. The canonical JAK/Stat pathway is integral to maintaining a normal immune system by stimulating proliferation, differentiation, survival and host resistance to pathogens. Altering JAK/Stat signaling to reduce cytokine induced pro-inflammatory responses represents an attractive target for anti-inflammatory therapies.

ALT Names :

Janus kinase 2;Tyrosine kinase

Immunogen :

KLH-conjugated linear peptide.

Specificity :

This antibody recognizes Jak2.

Package Size :

100 µg

Uses :

Western Blotting;Immunohistochemistry (Paraffin)

Storage :

Stable for 1 year at 2-8°C from date of receipt