RIPAb+™ G3BP1 - RIP Validated Antibody and Primer Set | EMD Millipore 03-180 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

RIPAb+™ G3BP1 - RIP Validated Antibody and Primer Set

catalog :

03-180

quantity :

10 assays

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

reactivity :

human

application :

western blot

product information

Catalog Number :

03-180

Subcategory :

Epigenetics & Nuclear Function

Product Name :

RIPAb+™ G3BP1 - RIP Validated Antibody and Primer Set

Product Type :

Antibodies

Clonality :

Monoclonal Antibody

Gene ID :

Q13283

Host Name :

Mouse

Antigen :

G3BP1

Conjugate :

Purified

Isotype :

IgG1κ

Product Description :

RIPAb+™ G3BP1 - RIP Validated Antibody and Primer Set

Cross Reactivity :

Human

Background :

G3BP1 (Ras-GTPase activating protein SH3-domain binding protein 1) directly associates with SH3 domains of GTPase activating proteins (GAPs). It was first discovered by its binding to RasGAP. G3BPs have been shown to be involved in a number of mitogenic signaling pathways. G3BP1 is also known to be over expressed in many human cancers (Kim, 2007) and its expression appears to be inversely correlated with PTEN expression (Kim, 2007). Interestingly, G3BP1, along with G3BP2, has been shown to bind to the C-terminus of p53, playing a crucial role in its activity (Kim, 2007). Furthermore, the G3BPs have two traditional RNA binding motifs.

ALT Names :

ATP-dependent DNA helicase VIII;GAP SH3 domain-binding protein 1;GAP binding protein;GTPase activating protein (SH3 domain) binding protein 1;Ras-GTPase-activating protein SH3-domain-binding protein;RasGAP-associated endoribonuclease G3BP

Immunogen :

GST-tagged recombinant protein corresponding to human G3BP1.

Specificity :

This antibody recognizes G3BP1.

Package Size :

10 assays

Uses :

RNA Binding Protein Immunoprecipitation (RIP);Western Blotting

Storage :

Stable for 1 year at -20°C from date of receipt. Handling Recommendations: Upon receipt, and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance. Note: Variability in freezer temperatures below -20°C may cause glycerol containing solutions to become frozen during storage.