RIPAb+ SMN - RIP Validated Antibody and Primer Set | EMD Millipore 03-178 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

RIPAb+ SMN - RIP Validated Antibody and Primer Set

catalog :

03-178

quantity :

10 assays

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

reactivity :

human, mouse

application :

western blot, immunocytochemistry

product information

Catalog Number :

03-178

Subcategory :

Epigenetics & Nuclear Function

Product Name :

RIPAb+ SMN - RIP Validated Antibody and Primer Set

Product Type :

Antibodies

Clonality :

Monoclonal Antibody

Gene ID :

Q16637

Host Name :

Mouse

Antigen :

SMN

Conjugate :

Purified

Isotype :

IgG1κ

Product Description :

RIPAb+ SMN - RIP Validated Antibody and Primer Set

Cross Reactivity :

Human;Mouse;Xenopus

Background :

The survival of motor neurons (SMN) protein is essential for the biogenesis of small nuclear RNA (snRNA)-ribonucleoproteins (snRNPs), the major components of the pre-mRNA splicing machinery. Though it is ubiquitously expressed, SMN deficiency causes the motor neuron degenerative disease spinal muscular atrophy (SMA). SMN deficiency has unexpected cell type-specific effects on the repertoire of snRNAs and mRNAs. It alters the stoichiometry of snRNAs and causes widespread pre-mRNA splicing defects in numerous transcripts of diverse genes, preferentially those containing a large number of introns, in SMN-deficient mouse tissues. The SMN complex plays a role in RNA metabolism and in splicing regulation.

ALT Names :

Component of gems 1;gemin 1;spinal muscular atrophy (Werdnig-Hoffmann disease, Kugelberg-Welander disease);survival of motor neuron 1, telomeric

Immunogen :

Histidine-tagged recombinant protein corresponding to human SMN.

Package Size :

10 assays

Uses :

RNA Binding Protein Immunoprecipitation (RIP);Western Blotting;Immunocytochemistry

Storage :

Stable for 1 year at -20°C from date of receipt. Handling Recommendations: Upon receipt, and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance. Note: Variability in freezer temperatures below -20°C may cause glycerol containing solutions to become frozen during storage.