product summary
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company name :
Dianova
product type :
antibody
product name :
Anti-mutated Calreticulin / CALR (Hu) from Mouse (Clone: CAL2) for FFPE tissue
catalog :
DIA-CAL-250
quantity :
250 µl
price :
698 EUR plus VAT
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
CAL2
reactivity :
human
application :
immunohistochemistry, immunohistochemistry - paraffin section
more info or order :
Dianova product webpage
citations: 2
Reference
Stein H, Bob R, Durkop H, Erck C, Kämpfe D, Kvasnicka H, et al. A new monoclonal antibody (CAL2) detects CALRETICULIN mutations in formalin-fixed and paraffin-embedded bone marrow biopsies. Leukemia. 2016;30:131-5 pubmed publisher
Nomani L, Bodo J, Zhao X, Durkin L, Loghavi S, Hsi E. CAL2 Immunohistochemical Staining Accurately Identifies CALR Mutations in Myeloproliferative Neoplasms. Am J Clin Pathol. 2016;146:431-8 pubmed publisher
image
image 1 :
Dianova DIA-CAL-250 image 1
Selective staining of mutated CALR protein in megakaryocytes of a PMF case in prefibrotic phase, in which Sanger sequencing detected a CALR mutation.
image 2 :
Dianova DIA-CAL-250 image 2
Selective staining of mutated CALR protein in megakaryocytes a PMF case in fibrotic phase, in which Sanger sequencing detected a CALR mutation.
product information
Catalog Number :
DIA-CAL-250
Product Name :
Anti-mutated Calreticulin / CALR (Hu) from Mouse (Clone: CAL2) for FFPE tissue
Product Type :
Antibody
Host Species :
Mouse
Clonality :
Monoclonal
Conjugation :
nonconjugated
Clone Name :
CAL2
Isotype :
IgG2a
Size :
250 µl
List Price :
698 EUR plus VAT
Product Description :
CAL2 labels the megakaryocytes in myeloproliferative neoplasms (essential thrombocythaemia (ET) and primary myelofibrosis (PMF)) with CALR mutation and enables to distinguish ET and PMF with CALR mutation from polycythemia vera (PV), from CALR mutation negative ET and PMF and from reactive bone marrow.
Immunogen :
C-neoterminus of mutated CALR
Localization :
Cytoplasmic
Specificity :
Human CALR protein expressed by all types of Exon 9 CALR mutations (deletion/insertion in 19p 13.3-13.2 of)
Purity :
Purified
Preservative :
0.05% NaN3
Application Summary :
IHC-P;IH
more info or order :
Dianova product webpage
company information
Dianova
Warburgstr. 45
D-20354 Hamburg
info@dianova.de
www.dianova.de
49 40 45 06 73 30
headquarters: Germany
Since its foundation in 1982, dianova GmbH provides professionals in Life Sciences with antibodies, immunoassays, and products for molecular biology. More than 30 years of grown expertise give rise to a fundamental knowledge about biochemical applications and a profound understanding of customer needs in research and routine diagnostic laboratories of universities, hospitals and the pharmaceutical industry.
Since its foundation in 1982, dianova GmbH provides professionals in Life Sciences with antibodies, immunoassays, and products for molecular biology. More than 30 years of grown expertise give rise to a fundamental knowledge about biochemical applications and a profound understanding of customer needs in research and routine diagnostic laboratories of universities, hospitals and the pharmaceutical industry.
In addition to distributing Life Science and Diagnostic Products in the German speaking region dianova manufactures and markets a series of antibodies with unique properties on a worldwide basis under the brand of optistain. To this end dianova has successfully established a distribution network in more than 25 countries.
At dianova quality is of paramount importance and subject to strict control. Internal controls and audits are carried out in addition to on-site inspections by independent, external inspection companies. In 2003 the TÜV Rheinland/Berlin/Brandenburg successfully completed the first comprehensive certification process. Since then dianova has been certified pursuant to the international DIN EN ISO 9001:2008 standard.