product summary
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company name :
Dianova
product type :
antibody
product name :
Anti-ATRX (Hu) from Mouse (Clone: AX1)
catalog :
DIA-AX1
quantity :
500 µl
price :
338 EUR plus VAT
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
AX1
reactivity :
human
application :
immunohistochemistry - paraffin section
more info or order :
Dianova product webpage
image
image 1 :
Dianova DIA-AX1 image 1
ATRX stain of 1p/19q deleted glioma
product information
Catalog Number :
DIA-AX1
Product Name :
Anti-ATRX (Hu) from Mouse (Clone: AX1)
Product Type :
Antibody
Host Species :
Mouse
Clonality :
Monoclonal
Conjugation :
nonconjugated
Clone Name :
AX1
Isotype :
IgG1
Light Chain :
kappa
Size :
500 µl
List Price :
338 EUR plus VAT
Product Description :
Antibody clone AX1 reacts specifically with ATRX in tissue sections from standard formalin-fixed brain tumor specimens.
Background :
ATRX is a member of the Snf2 family of helicases/ATPases, which contribute to the remodeling of nucleosome structure. ATRX mutation, IDH1 mutation and chromosomal 1p/19q co-deletion are key molecular factors for the subtype diagnosis of diffuse gliomas. ATRX mutations in gliomas result in the loss of nuclear ATRX expression, which can be diagnosed by IHC analysis. Loss of ATRX expression is close to being mutually exclusive to 1p/19q co-deletion. Consequently, ATRX immunohistochemistry can be performed to replace laborious analysis of 1p/19q status by FISH techniques. Combined immunohistochemistry of ATRX and IDH1R132H substitutes molecular testing. Astrocytoma very often harbour ATRX-mutations (>90%), wheras Oligodendroglioma typically do not (<5%). The routine practical approach for diagnosing astrocytomas and oligodendrogliomas begins with perfoming IHC for ATRX and IDH1 R132H expression. Stepwise analysis of molecular parameters with initial IHC for ATRX and IDH1 R132H followed by 1p/19q analysis and then by IDH sequencing significantly reduces the number of molecular tests required for unequivocal diagnosis (Reuss et al., 2015).
Immunogen :
Recombinant protein fragment of human ATRX
Specificity :
Human ATRX
Purity :
Purified
Preservative :
0.05% NaN3
Concentration :
0.2 mg/ml
Application Summary :
IHC-P
more info or order :
Dianova product webpage
company information
Dianova
Warburgstr. 45
D-20354 Hamburg
info@dianova.de
www.dianova.de
49 40 45 06 73 30
headquarters: Germany
Since its foundation in 1982, dianova GmbH provides professionals in Life Sciences with antibodies, immunoassays, and products for molecular biology. More than 30 years of grown expertise give rise to a fundamental knowledge about biochemical applications and a profound understanding of customer needs in research and routine diagnostic laboratories of universities, hospitals and the pharmaceutical industry.
Since its foundation in 1982, dianova GmbH provides professionals in Life Sciences with antibodies, immunoassays, and products for molecular biology. More than 30 years of grown expertise give rise to a fundamental knowledge about biochemical applications and a profound understanding of customer needs in research and routine diagnostic laboratories of universities, hospitals and the pharmaceutical industry.
In addition to distributing Life Science and Diagnostic Products in the German speaking region dianova manufactures and markets a series of antibodies with unique properties on a worldwide basis under the brand of optistain. To this end dianova has successfully established a distribution network in more than 25 countries.
At dianova quality is of paramount importance and subject to strict control. Internal controls and audits are carried out in addition to on-site inspections by independent, external inspection companies. In 2003 the TÜV Rheinland/Berlin/Brandenburg successfully completed the first comprehensive certification process. Since then dianova has been certified pursuant to the international DIN EN ISO 9001:2008 standard.