product summary
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company name :
Dianova
product type :
antibody
product name :
Anti-GFAP (Hu) from Mouse (Clone: IF3)
catalog :
DIA-700-P05
quantity :
500 µl
price :
167 EUR plus VAT
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
IF3
reactivity :
human
application :
immunohistochemistry, immunohistochemistry - paraffin section
more info or order :
Dianova product webpage
product information
Catalog Number :
DIA-700-P05
Product Name :
Anti-GFAP (Hu) from Mouse (Clone: IF3)
Product Type :
Antibody
Host Species :
Mouse
Clonality :
Monoclonal
Conjugation :
nonconjugated
Clone Name :
IF3
Isotype :
IgG1
Size :
500 µl
List Price :
167 EUR plus VAT
Product Description :
GFAP (Glial Fibrillary Acidic Protein) has proved to be the most specific marker for cells of astrocytic origin that distinguishes differentiated astrocytes from other glial cells during the development of the central nervous system. Monoclonal antibodies to GFAP are useful in differentiating primary gliomas from metastatic lesions in the brain and for documenting astrocytic differentiation in tumors outside the CNS.
Background :
As a 50 kDa intracytoplasmic filamentous protein, GFAP is thought to be important in astrocyte motility and shape by providing structural stability. As a consequence of injury to the human CNS caused by trauma, genetic disorders, or chemicals, GFAP is markly upregulated and astrocytes proliferate. On the other hand, with increasing astrocyte malignancy, a progressive loss of GFAP production has been observed. Consequntly, malignant astrocytomas have fewer tumour cells that stain positively and intensely for GFAP than do less malignant astrocytomas and normal brain specimens. Outside the CNS, GFAP has been demonstrated in Schwann cells, enteric glia cells, salivary gland neoplasms, and metastasizing renal carcinomas. Moreover, GFAP has been detected in epiglottic cartilage, pituicytes, immature oligodendrocytes, papillary meningiomas, and myoepithelial cells of the breast.
ALTnames :
Glial Fibrillary Acidic Protein
Specificity :
Human GFAP
Purity :
Purified
Preservative :
0.05% NaN3
Application Summary :
IHC-P;IH
more info or order :
Dianova product webpage
company information
Dianova
Warburgstr. 45
D-20354 Hamburg
info@dianova.de
www.dianova.de
49 40 45 06 73 30
headquarters: Germany
Since its foundation in 1982, dianova GmbH provides professionals in Life Sciences with antibodies, immunoassays, and products for molecular biology. More than 30 years of grown expertise give rise to a fundamental knowledge about biochemical applications and a profound understanding of customer needs in research and routine diagnostic laboratories of universities, hospitals and the pharmaceutical industry.
Since its foundation in 1982, dianova GmbH provides professionals in Life Sciences with antibodies, immunoassays, and products for molecular biology. More than 30 years of grown expertise give rise to a fundamental knowledge about biochemical applications and a profound understanding of customer needs in research and routine diagnostic laboratories of universities, hospitals and the pharmaceutical industry.
In addition to distributing Life Science and Diagnostic Products in the German speaking region dianova manufactures and markets a series of antibodies with unique properties on a worldwide basis under the brand of optistain. To this end dianova has successfully established a distribution network in more than 25 countries.
At dianova quality is of paramount importance and subject to strict control. Internal controls and audits are carried out in addition to on-site inspections by independent, external inspection companies. In 2003 the TÜV Rheinland/Berlin/Brandenburg successfully completed the first comprehensive certification process. Since then dianova has been certified pursuant to the international DIN EN ISO 9001:2008 standard.