product summary
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company name :
Dianova
product type :
antibody
product name :
Anti-p53 (Hu) from Mouse (Clone: CC53)
catalog :
DIA-530-P05
quantity :
500 µl
price :
167 EUR plus VAT
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
CC53
reactivity :
human
application :
immunohistochemistry - paraffin section
more info or order :
Dianova product webpage
image
image 1 :
Dianova DIA-530-P05 image 1
(A) Squamous cell carcinoma of the neck. Nearly all tumor cells are strongly p53 positive in their nuclei. (B) Colon carcinoma. Nearly all tumor cells are strongly p53 positive in their nuclei.
product information
Catalog Number :
DIA-530-P05
Product Name :
Anti-p53 (Hu) from Mouse (Clone: CC53)
Product Type :
Antibody
Host Species :
Mouse
Clonality :
Monoclonal
Conjugation :
nonconjugated
Clone Name :
CC53
Isotype :
IgG1
Size :
500 µl
List Price :
167 EUR plus VAT
Background :
The p53 tumor suppressor gene has been found to contain mutations in over 50% of human cancers. Many mutations of the p53 gene have been associated with malignant transformation in a wide variety of human tumors. p53 immunostaining is of use in demonstrating accumulation of p53 protein, which occurs in a high frequency in a wide variety of transformed cells. Anti-p53 Tumor Suppressor Protein antibody recognizes a 53 kDa phosphoprotein, identified as p53 suppressor gene product. It reacts with the mutant as well as wild form of p53. Positive nuclear staining with this antibody has been shown to be a negative prognostic factor in Breast carcinoma, Lung carcinoma, Colorectal, and Urothelial carcinoma. p53 positivity has also been used to differentiate Uterine serous carcinoma from endometrioid carcinoma as well as to detect Intratubular germ cell neoplasia. Moreover antibody clone CC53 helps to detect single invading astrocytoma-cells
Immunogen :
Recombinant, human wild type p53
Localization :
Nuclear
Specificity :
Human p53, wild type and mutated
Purity :
Purified
Preservative :
0.05% NaN3
Application Summary :
IHC-P
more info or order :
Dianova product webpage
company information
Dianova
Warburgstr. 45
D-20354 Hamburg
info@dianova.de
www.dianova.de
49 40 45 06 73 30
headquarters: Germany
Since its foundation in 1982, dianova GmbH provides professionals in Life Sciences with antibodies, immunoassays, and products for molecular biology. More than 30 years of grown expertise give rise to a fundamental knowledge about biochemical applications and a profound understanding of customer needs in research and routine diagnostic laboratories of universities, hospitals and the pharmaceutical industry.
Since its foundation in 1982, dianova GmbH provides professionals in Life Sciences with antibodies, immunoassays, and products for molecular biology. More than 30 years of grown expertise give rise to a fundamental knowledge about biochemical applications and a profound understanding of customer needs in research and routine diagnostic laboratories of universities, hospitals and the pharmaceutical industry.
In addition to distributing Life Science and Diagnostic Products in the German speaking region dianova manufactures and markets a series of antibodies with unique properties on a worldwide basis under the brand of optistain. To this end dianova has successfully established a distribution network in more than 25 countries.
At dianova quality is of paramount importance and subject to strict control. Internal controls and audits are carried out in addition to on-site inspections by independent, external inspection companies. In 2003 the TÜV Rheinland/Berlin/Brandenburg successfully completed the first comprehensive certification process. Since then dianova has been certified pursuant to the international DIN EN ISO 9001:2008 standard.