product summary
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company name :
Dianova
product type :
antibody
product name :
Anti-CD4 (Ms) from Rat (Clone: GHH4) for mouse FFPE tissue
catalog :
DIA-404
quantity :
200 µl
price :
345 EUR plus VAT
clonality :
monoclonal
host :
rat
conjugate :
nonconjugated
clone name :
GHH4
reactivity :
mouse
application :
immunohistochemistry - paraffin section
more info or order :
Dianova product webpage
image
image 1 :
Dianova DIA-404 image 1
The monoclonal antibody clone GHH4 specifically stains CD4 in standard FFPE mouse spleen.
product information
Catalog Number :
DIA-404
Product Name :
Anti-CD4 (Ms) from Rat (Clone: GHH4) for mouse FFPE tissue
Product Type :
Antibody
Host Species :
Rat
Clonality :
Monoclonal
Conjugation :
nonconjugated
Clone Name :
GHH4
Isotype :
IgG2b
Light Chain :
kappa
Size :
200 µl
List Price :
345 EUR plus VAT
Product Description :
Antibody clone GHH4 has been developed and validated for the detection of murine CD4 in formalin-fixed paraffin-embedded tissue sections (mouse FFPE). Clone GHH4 identifies T helper cells in murine FFPE tissue by IHC.
Background :
CD4 is a marker for T helper cells. Besides this subpopulation of mature T cells (helper/inducer), CD4 is also expressed on most thymocytes and weakly on macrophages and dendritic cells. Antigen recognition and subsequent T-cell activation is controlled by the interaction between TCR (T-cell receptor) and pMHC (peptide-major histocompatibility complexe). T-cell activation is often enhanced by a close cooperation of the TCR with two different co-receptors: CD8 and CD4. Cluster of Differentiation 4 (CD4) is a nonpolymorphous 55 kDa glycoprotein belonging to the immunoglobulin superfamily. It acts as a co-receptor with the TCR during antigen-induced T cell activation and thymic differentiation by binding MHC class II and plays an important role both in T cell development and in optimal functioning of mature T cells. In T cells, CD4 associates with protein tyrosine kinase p56lck through its cytoplasmic tail. In humans, CD4 is expressed in the majority of T-cell lymphomas. CD4 plays an important role in the classification of lymphocytes in inflammatory lesions and malignant lymphomas. CD4 serves as HIV receptor on T cells, macrophages and brain and is downregulated by HIV proteins during AIDS progression.
Immunogen :
Recombinant protein of mouse CD4
Specificity :
Mouse CD4
Purity :
Purified
Preservative :
0.05% NaN3
Concentration :
1.0 mg/ml
Application Summary :
IHC-P;other not tested
more info or order :
Dianova product webpage
company information
Dianova
Warburgstr. 45
D-20354 Hamburg
info@dianova.de
www.dianova.de
49 40 45 06 73 30
headquarters: Germany
Since its foundation in 1982, dianova GmbH provides professionals in Life Sciences with antibodies, immunoassays, and products for molecular biology. More than 30 years of grown expertise give rise to a fundamental knowledge about biochemical applications and a profound understanding of customer needs in research and routine diagnostic laboratories of universities, hospitals and the pharmaceutical industry.
Since its foundation in 1982, dianova GmbH provides professionals in Life Sciences with antibodies, immunoassays, and products for molecular biology. More than 30 years of grown expertise give rise to a fundamental knowledge about biochemical applications and a profound understanding of customer needs in research and routine diagnostic laboratories of universities, hospitals and the pharmaceutical industry.
In addition to distributing Life Science and Diagnostic Products in the German speaking region dianova manufactures and markets a series of antibodies with unique properties on a worldwide basis under the brand of optistain. To this end dianova has successfully established a distribution network in more than 25 countries.
At dianova quality is of paramount importance and subject to strict control. Internal controls and audits are carried out in addition to on-site inspections by independent, external inspection companies. In 2003 the TÜV Rheinland/Berlin/Brandenburg successfully completed the first comprehensive certification process. Since then dianova has been certified pursuant to the international DIN EN ISO 9001:2008 standard.