product summary
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company name :
Dianova
product type :
antibody
product name :
Anti-CD31 (Ms) from Rat (Clone: SZ31) for mouse FFPE tissue
catalog :
DIA-310
quantity :
500 µl
clonality :
monoclonal
host :
rat
conjugate :
nonconjugated
clone name :
SZ31
reactivity :
human, mouse
application :
western blot, immunohistochemistry, immunocytochemistry, immunohistochemistry - paraffin section, immunohistochemistry - frozen section, immunohistochemistry - free floating section
more info or order :
citations: 112
Published Application/Species/Sample/DilutionReference
  • immunohistochemistry; human; loading ...; fig 7c
Kaminski M, Bendzick L, Hopps R, Kauffman M, Kodal B, Soignier Y, et al. TEM8 Tri-specific Killer Engager binds both tumor and tumor stroma to specifically engage natural killer cell anti-tumor activity. J Immunother Cancer. 2022;10: pubmed publisher
  • immunohistochemistry - paraffin section; mouse; loading ...; fig 1a
Wrublewsky S, Glas J, Carlein C, Nalbach L, Hoffmann M, Pack M, et al. The loss of pancreatic islet NADPH oxidase (NOX)2 improves islet transplantation. Redox Biol. 2022;55:102419 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; loading ...; fig 3b, s1a
Feng S, Peden E, Guo Q, Lee T, Li Q, Yuan Y, et al. Downregulation of the endothelial histone demethylase JMJD3 is associated with neointimal hyperplasia of arteriovenous fistulas in kidney failure. J Biol Chem. 2022;298:101816 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; 1:10; loading ...; fig 7f
Kettwig M, Ternka K, Wendland K, Krüger D, Zampar S, Schob C, et al. Interferon-driven brain phenotype in a mouse model of RNaseT2 deficient leukoencephalopathy. Nat Commun. 2021;12:6530 pubmed publisher
  • immunohistochemistry; mouse; loading ...; fig s2
Gurley J, Gmyrek G, Hargis E, Bishop G, Carr D, Elliott M. The Chx10-Traf3 Knockout Mouse as a Viable Model to Study Neuronal Immune Regulation. Cells. 2021;10: pubmed publisher
  • immunohistochemistry - paraffin section; mouse; fig 7e
Bruand M, Barras D, Mina M, Ghisoni E, Morotti M, Lanitis E, et al. Cell-autonomous inflammation of BRCA1-deficient ovarian cancers drives both tumor-intrinsic immunoreactivity and immune resistance via STING. Cell Rep. 2021;36:109412 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; loading ...; fig 3f
Yan C, Saleh N, Yang J, Nebhan C, Vilgelm A, Reddy E, et al. Novel induction of CD40 expression by tumor cells with RAS/RAF/PI3K pathway inhibition augments response to checkpoint blockade. Mol Cancer. 2021;20:85 pubmed publisher
  • immunohistochemistry; mouse; 1:200; loading ...; fig 2e
Komeno M, Pang X, Shimizu A, Molla M, Yasuda Yamahara M, Kume S, et al. Cardio- and reno-protective effects of dipeptidyl peptidase III in diabetic mice. J Biol Chem. 2021;296:100761 pubmed publisher
  • immunohistochemistry; mouse; 1:50; loading ...; fig 4a
Moore K, Fulmer D, Guo L, Koren N, Glover J, Moore R, et al. PDGFRα: Expression and Function during Mitral Valve Morphogenesis. J Cardiovasc Dev Dis. 2021;8: pubmed publisher
  • immunohistochemistry - paraffin section; mouse; 1:100; loading ...; fig 5b
Zarb Y, Sridhar S, Nassiri S, Utz S, Schaffenrath J, Maheshwari U, et al. Microglia control small vessel calcification via TREM2. Sci Adv. 2021;7: pubmed publisher
  • immunohistochemistry; mouse; 1:100; loading ...; fig 4d
Klemke L, De Oliveira T, Witt D, Winkler N, Bohnenberger H, Bucala R, et al. Hsp90-stabilized MIF supports tumor progression via macrophage recruitment and angiogenesis in colorectal cancer. Cell Death Dis. 2021;12:155 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; 1:100; loading ...; fig s4
Gurley J, Gmyrek G, McClellan M, Hargis E, Hauck S, Dozmorov M, et al. Neuroretinal-Derived Caveolin-1 Promotes Endotoxin-Induced Inflammation in the Murine Retina. Invest Ophthalmol Vis Sci. 2020;61:19 pubmed publisher
  • immunohistochemistry; mouse; 1:200; loading ...; fig 2a
Alonso Herranz L, Sahún Español Á, Paredes A, Gonzalo P, Gkontra P, Núñez V, et al. Macrophages promote endothelial-to-mesenchymal transition via MT1-MMP/TGFβ1 after myocardial infarction. elife. 2020;9: pubmed publisher
  • immunohistochemistry - paraffin section; mouse; fig 5f
Schmitt B, Boewe A, Becker V, Nalbach L, Gu Y, Götz C, et al. Protein Kinase CK2 Regulates Nerve/Glial Antigen (NG)2-Mediated Angiogenic Activity of Human Pericytes. Cells. 2020;9: pubmed publisher
  • immunohistochemistry; mouse; 1:50; loading ...; fig 8e
Devraj G, Guérit S, Seele J, Spitzer D, Macas J, Khel M, et al. HIF-1α is involved in blood-brain barrier dysfunction and paracellular migration of bacteria in pneumococcal meningitis. Acta Neuropathol. 2020;140:183-208 pubmed publisher
  • immunohistochemistry; mouse; 1:1000; loading ...; fig 3c
Resovi A, Borsotti P, Ceruti T, Passoni A, Zucchetti M, Berndt A, et al. CCN-Based Therapeutic Peptides Modify Pancreatic Ductal Adenocarcinoma Microenvironment and Decrease Tumor Growth in Combination with Chemotherapy. Cells. 2020;9: pubmed publisher
  • immunohistochemistry - paraffin section; mouse; 1:600; loading ...; fig 6a
Facchin C, Pérez Liva M, Garofalakis A, Viel T, Certain A, Balvay D, et al. Concurrent imaging of vascularization and metabolism in a mouse model of paraganglioma under anti-angiogenic treatment. Theranostics. 2020;10:3518-3532 pubmed publisher
  • immunohistochemistry - frozen section; mouse; 1:100; loading ...; fig 1a, 7s4b
Engelbrecht E, Lévesque M, He L, Vanlandewijck M, Nitzsche A, Niazi H, et al. Sphingosine 1-phosphate-regulated transcriptomes in heterogenous arterial and lymphatic endothelium of the aorta. elife. 2020;9: pubmed publisher
  • immunohistochemistry - free floating section; mouse; 1:250; loading ...; fig 6d
Collins L, Brunjes P. The mouse olfactory peduncle 4: Development of synapses, perineuronal nets, and capillaries. J Comp Neurol. 2019;: pubmed publisher
  • immunohistochemistry - paraffin section; mouse; 1:100; loading ...; fig 6h
Farbehi N, Patrick R, Dorison A, Xaymardan M, Janbandhu V, Wystub Lis K, et al. Single-cell expression profiling reveals dynamic flux of cardiac stromal, vascular and immune cells in health and injury. elife. 2019;8: pubmed publisher
  • immunohistochemistry; mouse; 1:100; loading ...; fig 3s1b
Basnet H, Tian L, Ganesh K, Huang Y, Macalinao D, Brogi E, et al. Flura-seq identifies organ-specific metabolic adaptations during early metastatic colonization. elife. 2019;8: pubmed publisher
  • immunohistochemistry - frozen section; mouse; 1:250; loading ...; fig 1f
  • immunohistochemistry; mouse; 1:250; loading ...; fig 5a
Hess D, Kelly Goss M, Cherepanova O, Nguyen A, Baylis R, Tkachenko S, et al. Perivascular cell-specific knockout of the stem cell pluripotency gene Oct4 inhibits angiogenesis. Nat Commun. 2019;10:967 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; loading ...; fig 4
Low S, Hirakawa J, Hoshino H, Uchimura K, Kawashima H, Kobayashi M. Role of MAdCAM-1-Expressing High Endothelial Venule-Like Vessels in Colitis Induced in Mice Lacking Sulfotransferases Catalyzing L-Selectin Ligand Biosynthesis. J Histochem Cytochem. 2018;66:415-425 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; 1:20; loading ...; fig s5a
Tang A, Choi J, Kotzin J, Yang Y, Hong C, Hobson N, et al. Endothelial TLR4 and the microbiome drive cerebral cavernous malformations. Nature. 2017;545:305-310 pubmed publisher
  • immunohistochemistry - free floating section; mouse; 1:100; loading ...; fig s3
  • western blot; mouse; 1:2000; loading ...; fig 3b
Yanagida K, Liu C, Faraco G, Galvani S, Smith H, Burg N, et al. Size-selective opening of the blood-brain barrier by targeting endothelial sphingosine 1-phosphate receptor 1. Proc Natl Acad Sci U S A. 2017;114:4531-4536 pubmed publisher
  • immunohistochemistry; mouse; 1 ug/ml; loading ...; fig S5
Fonseca M, Chu S, Hernandez M, Fang M, Modarresi L, Selvan P, et al. Cell-specific deletion of C1qa identifies microglia as the dominant source of C1q in mouse brain. J Neuroinflammation. 2017;14:48 pubmed publisher
  • immunohistochemistry; human; fig 55
  • immunohistochemistry - paraffin section; mouse; 2 ug/ml
Furukawa S, Nagaike M, Ozaki K. Databases for technical aspects of immunohistochemistry. J Toxicol Pathol. 2017;30:79-107 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; loading ...; fig 5l
Patschan D, Schwarze K, Tampe B, Zeisberg M, Patschan S, Muller G. Endothelial Colony Forming Cells (ECFCs) in murine AKI - implications for future cell-based therapies. BMC Nephrol. 2017;18:53 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; 1:100; loading ...; fig s2a
de Jong R, Paulin N, Lemnitzer P, Viola J, Winter C, Ferraro B, et al. Protective Aptitude of Annexin A1 in Arterial Neointima Formation in Atherosclerosis-Prone Mice-Brief Report. Arterioscler Thromb Vasc Biol. 2017;37:312-315 pubmed publisher
  • immunohistochemistry - paraffin section; human; 0.5 ug/ml; loading ...; fig 4a
Nayak T, Andreou C, Oseledchyk A, Marcus W, Wong H, Massague J, et al. Tissue factor-specific ultra-bright SERRS nanostars for Raman detection of pulmonary micrometastases. Nanoscale. 2017;9:1110-1119 pubmed publisher
  • western blot; mouse; loading ...
Kühnel E, Kleff V, Stojanovska V, Kaiser S, Waldschütz R, Herse F, et al. Placental-Specific Overexpression of sFlt-1 Alters Trophoblast Differentiation and Nutrient Transporter Expression in an IUGR Mouse Model. J Cell Biochem. 2017;118:1316-1329 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; 1:100; loading ...; fig s10d
Goebbels S, Wieser G, Pieper A, Spitzer S, Weege B, Yan K, et al. A neuronal PI(3,4,5)P3-dependent program of oligodendrocyte precursor recruitment and myelination. Nat Neurosci. 2017;20:10-15 pubmed publisher
  • immunohistochemistry; human; 1:75; loading ...; fig s14
Frentzas S, Simoneau E, Bridgeman V, Vermeulen P, Foo S, Kostaras E, et al. Vessel co-option mediates resistance to anti-angiogenic therapy in liver metastases. Nat Med. 2016;22:1294-1302 pubmed publisher
  • immunocytochemistry; mouse; 1:200; fig 2
Klose R, Krzywinska E, Castells M, Gotthardt D, Putz E, Kantari Mimoun C, et al. Targeting VEGF-A in myeloid cells enhances natural killer cell responses to chemotherapy and ameliorates cachexia. Nat Commun. 2016;7:12528 pubmed publisher
  • western blot; mouse; fig 6
Inoue T, Ikeda M, Ide T, Fujino T, Matsuo Y, Arai S, et al. Twinkle overexpression prevents cardiac rupture after myocardial infarction by alleviating impaired mitochondrial biogenesis. Am J Physiol Heart Circ Physiol. 2016;311:H509-19 pubmed publisher
  • immunocytochemistry; mouse; 1:20; fig s3
Chen I, Caprioli A, Ohnuki H, Kwak H, Porcher C, Tosato G. EphrinB2 regulates the emergence of a hemogenic endothelium from the aorta. Sci Rep. 2016;6:27195 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; 1:100; loading ...; fig 5d
Osterloh A, Papp S, Moderzynski K, Kuehl S, Richardt U, Fleischer B. Persisting Rickettsia typhi Causes Fatal Central Nervous System Inflammation. Infect Immun. 2016;84:1615-1632 pubmed publisher
  • immunohistochemistry; mouse; 1:50; fig 3
Kraft Sheleg O, Zaffryar Eilot S, Genin O, Yaseen W, Soueid Baumgarten S, Kessler O, et al. Localized LoxL3-Dependent Fibronectin Oxidation Regulates Myofiber Stretch and Integrin-Mediated Adhesion. Dev Cell. 2016;36:550-61 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; fig 4
Rusckowski M, Wang Y, Blankenberg F, Levashova Z, Backer M, Backer J. Targeted scVEGF/(177)Lu radiopharmaceutical inhibits growth of metastases and can be effectively combined with chemotherapy. EJNMMI Res. 2016;6:4 pubmed publisher
  • immunohistochemistry - frozen section; mouse
  • immunohistochemistry - paraffin section; mouse; fig 5
Dimitrova N, Gocheva V, Bhutkar A, Resnick R, Jong R, Miller K, et al. Stromal Expression of miR-143/145 Promotes Neoangiogenesis in Lung Cancer Development. Cancer Discov. 2016;6:188-201 pubmed publisher
  • immunocytochemistry; human; 1:20; fig 2b
Mikami J, Kurokawa Y, Takahashi T, Miyazaki Y, Yamasaki M, Miyata H, et al. Antitumor effect of antiplatelet agents in gastric cancer cells: an in vivo and in vitro study. Gastric Cancer. 2016;19:817-26 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; 1:150; fig 7
Janssen L, Dupont L, Bekhouche M, Noel A, Leduc C, Voz M, et al. ADAMTS3 activity is mandatory for embryonic lymphangiogenesis and regulates placental angiogenesis. Angiogenesis. 2016;19:53-65 pubmed publisher
  • immunohistochemistry; mouse; 1:25; fig 6a
Mangiavini L, Merceron C, Araldi E, Khatri R, Gerard O Riley R, Wilson T, et al. Fibrosis and hypoxia-inducible factor-1α-dependent tumors of the soft tissue on loss of von Hippel-Lindau in mesenchymal progenitors. Am J Pathol. 2015;185:3090-101 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; fig 3
Dmitrieva N, Burg M. Elevated sodium and dehydration stimulate inflammatory signaling in endothelial cells and promote atherosclerosis. PLoS ONE. 2015;10:e0128870 pubmed publisher
  • immunohistochemistry; mouse; loading ...; fig 3
Yarilin D, Xu K, Turkekul M, Fan N, Romin Y, Fijisawa S, et al. Machine-based method for multiplex in situ molecular characterization of tissues by immunofluorescence detection. Sci Rep. 2015;5:9534 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; 1:100; loading ...; fig 1c
Salvucci O, Ohnuki H, Maric D, Hou X, Li X, Yoon S, et al. EphrinB2 controls vessel pruning through STAT1-JNK3 signalling. Nat Commun. 2015;6:6576 pubmed publisher
  • immunohistochemistry; mouse; 1:50; loading ...; fig 2a
  • immunohistochemistry; human; 1:50; loading ...; fig s3c
Grabner B, Schramek D, Mueller K, Moll H, Svinka J, Hoffmann T, et al. Disruption of STAT3 signalling promotes KRAS-induced lung tumorigenesis. Nat Commun. 2015;6:6285 pubmed publisher
  • immunohistochemistry - paraffin section; human; 1:50; fig st4
Goossens S, Radaelli E, Blanchet O, Durinck K, Van der Meulen J, Peirs S, et al. ZEB2 drives immature T-cell lymphoblastic leukaemia development via enhanced tumour-initiating potential and IL-7 receptor signalling. Nat Commun. 2015;6:5794 pubmed publisher
Astone M, Oberkersch R, Tosi G, Biscontin A, Santoro M. The circadian protein BMAL1 supports endothelial cell cycle during angiogenesis. Cardiovasc Res. 2023;: pubmed publisher
Yang F, Kalantari S, Ruan B, Sun S, Bian Z, Guan J. Autophagy inhibition prevents lymphatic malformation progression to lymphangiosarcoma by decreasing osteopontin and Stat3 signaling. Nat Commun. 2023;14:978 pubmed publisher
Huang M, Yang F, Zhang D, Lin M, Duan H, El Mayta R, et al. Endothelial plasticity drives aberrant vascularization and impedes cardiac repair after myocardial infarction. Nat Cardiovasc Res. 2022;1:372-388 pubmed publisher
Sánchez López A, Espinós Estévez C, Gonzalez Gomez C, Gonzalo P, Andrés Manzano M, Fanjul V, et al. Cardiovascular Progerin Suppression and Lamin A Restoration Rescue Hutchinson-Gilford Progeria Syndrome. Circulation. 2021;144:1777-1794 pubmed publisher
Menger M, Nalbach L, Roma L, Laschke M, Menger M, Ampofo E. Erythropoietin exposure of isolated pancreatic islets accelerates their revascularization after transplantation. Acta Diabetol. 2021;58:1637-1647 pubmed publisher
Driskill J, Zheng Y, Wu B, Wang L, Cai J, Rakheja D, et al. WWTR1(TAZ)-CAMTA1 reprograms endothelial cells to drive epithelioid hemangioendothelioma. Genes Dev. 2021;35:495-511 pubmed publisher
Hultgren N, Fang J, Ziegler M, Ramirez R, Phan D, Hatch M, et al. Slug regulates the Dll4-Notch-VEGFR2 axis to control endothelial cell activation and angiogenesis. Nat Commun. 2020;11:5400 pubmed publisher
Li H, Bi Y, Li Y, Fu R, Lv W, Jiang N, et al. A potent CBP/p300-Snail interaction inhibitor suppresses tumor growth and metastasis in wild-type p53-expressing cancer. Sci Adv. 2020;6:eaaw8500 pubmed publisher
Becker L, O Connell J, Vo A, Cain M, Tampe D, Bizarro L, et al. Epigenetic Reprogramming of Cancer-Associated Fibroblasts Deregulates Glucose Metabolism and Facilitates Progression of Breast Cancer. Cell Rep. 2020;31:107701 pubmed publisher
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Liu T, Ma W, Xu H, Huang M, Zhang D, He Z, et al. PDGF-mediated mesenchymal transformation renders endothelial resistance to anti-VEGF treatment in glioblastoma. Nat Commun. 2018;9:3439 pubmed publisher
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Botusan I, Zheng X, Narayanan S, Grunler J, Sunkari V, Calissendorff F, et al. Deficiency of liver-derived insulin-like growth factor-I (IGF-I) does not interfere with the skin wound healing rate. PLoS ONE. 2018;13:e0193084 pubmed publisher
Kim K, Watson P, Lebdai S, Jebiwott S, Somma A, La Rosa S, et al. Androgen Deprivation Therapy Potentiates the Efficacy of Vascular Targeted Photodynamic Therapy of Prostate Cancer Xenografts. Clin Cancer Res. 2018;24:2408-2416 pubmed publisher
Mahany E, Han X, Borges B, da Silveira Cruz Machado S, Allen S, García Galiano D, et al. Obesity and High-Fat Diet Induce Distinct Changes in Placental Gene Expression and Pregnancy Outcome. Endocrinology. 2018;159:1718-1733 pubmed publisher
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product information
Catalog Number :
DIA-310
Product Name :
Anti-CD31 (Ms) from Rat (Clone: SZ31) for mouse FFPE tissue
Product Type :
Antibody
Host Species :
Rat
Clonality :
Monoclonal
Conjugation :
nonconjugated
Clone Name :
SZ31
Isotype :
IgG2a
Size :
500 µl
Product Description :
Antibody clone SZ31 is the first antibody which reacts specifically with murine CD31 in formalin-fixed paraffin-embedded tissue sections.
CrossReactivity :
does not cross-react with rat or human
Background :
CD31, also known as PECAM-1 (Platelet Endothelial Cell Adhesion Molecule-1) is expressed constitutively on the surface of embryonic and adult endothelial cells. It is also expressed on cell surfaces of monocytes, neutrophils, platelets and certain T-cell subsets. It has been detected on bone marrow-derived hematopoetic stem cells and embryonic stem cells. Cluster of Differentiation 31 (CD31) is a 130kDa integral membrane glycoprotein and as a member of the immunoglobulin superfamily involved in the mediation of cell-to-cell adhesion. CD31-mediated endothelial cell-cell interactions play a major role in angiogenesis. Studies have shown CD31 to be a superior marker in human angiogenesis, which reportedly predicts tumor recurrence. Pathophysiological studies of CD31 in murine model systems had limitations because standard formalin-fixed sections were excluded. The clone SZ31 (Anti-CD31) eliminates these restrictions by allowing high quality immunohistochemical analysis of standard formalin-fixed paraffin sections in mice.
ALTnames :
PECAM-1 (Platelet Endothelial Cell Adhesion Molecule-1)
Immunogen :
Murine amino acid fragment
Specificity :
Murine CD31 (PECAM-1) (adult and embryonic endothelial cells)
Purity :
Purified
Preservative :
0.05% NaN3
Concentration :
0.2 mg/ml
Application Summary :
IHC-F;IHC-P;WB
more info or order :
company information
Dianova
Warburgstr. 45
D-20354 Hamburg
info@dianova.de
http://www.dianova.de
49 40 45 06 73 30
headquarters: Germany
Since its foundation in 1982, dianova GmbH provides professionals in Life Sciences with antibodies, immunoassays, and products for molecular biology. More than 30 years of grown expertise give rise to a fundamental knowledge about biochemical applications and a profound understanding of customer needs in research and routine diagnostic laboratories of universities, hospitals and the pharmaceutical industry.
Since its foundation in 1982, dianova GmbH provides professionals in Life Sciences with antibodies, immunoassays, and products for molecular biology. More than 30 years of grown expertise give rise to a fundamental knowledge about biochemical applications and a profound understanding of customer needs in research and routine diagnostic laboratories of universities, hospitals and the pharmaceutical industry.
In addition to distributing Life Science and Diagnostic Products in the German speaking region dianova manufactures and markets a series of antibodies with unique properties on a worldwide basis under the brand of optistain. To this end dianova has successfully established a distribution network in more than 25 countries.
At dianova quality is of paramount importance and subject to strict control. Internal controls and audits are carried out in addition to on-site inspections by independent, external inspection companies. In 2003 the TÜV Rheinland/Berlin/Brandenburg successfully completed the first comprehensive certification process. Since then dianova has been certified pursuant to the international DIN EN ISO 9001:2008 standard.