mineralocorticoid receptor | Developmental Studies Hybridoma Bank rMR1-18 1D5 product information

product summary

company name :

Developmental Studies Hybridoma Bank

product type :

antibody

product name :

mineralocorticoid receptor

catalog :

rMR1-18 1D5

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

rMR1-18 1D5

reactivity :

human, mouse, rat, dog, chicken

application :

western blot, ELISA, immunohistochemistry, immunocytochemistry, immunoprecipitation, chromatin immunoprecipitation

more info or order :

Developmental Studies Hybridoma Bank product webpage

citations: 12

Published Application/Species/Sample/Dilution	Reference
western blot; rat	Sase S, Meyer K, Lubec G, Korz V. Different expression of membrane-bound and cytosolic hippocampal steroid receptor complexes during spatial training in young male rats. Eur Neuropsychopharmacol. 2014;24:1819-27 pubmed publisher
	Dougherty E, Elinoff J, Ferreyra G, Hou A, Cai R, Sun J, et al. Mineralocorticoid Receptor (MR) trans-Activation of Inflammatory AP-1 Signaling: DEPENDENCE ON DNA SEQUENCE, MR CONFORMATION, AND AP-1 FAMILY MEMBER EXPRESSION. J Biol Chem. 2016;291:23628-23644 pubmed
	Petrovich E, Asher C, Garty H. Induction of FKBP51 by aldosterone in intestinal epithelium. J Steroid Biochem Mol Biol. 2014;139:78-87 pubmed publisher
	Richards J, Jeffers L, All S, Cheng K, Gumz M. Role of Per1 and the mineralocorticoid receptor in the coordinate regulation of ?ENaC in renal cortical collecting duct cells. Front Physiol. 2013;4:253 pubmed publisher
	Meinel S, Ruhs S, Schumann K, Strätz N, Trenkmann K, Schreier B, et al. Mineralocorticoid receptor interaction with SP1 generates a new response element for pathophysiologically relevant gene expression. Nucleic Acids Res. 2013;41:8045-60 pubmed publisher
	Salyer S, Parks J, Barati M, Lederer E, Clark B, Klein J, et al. Aldosterone regulates Na(+), K(+) ATPase activity in human renal proximal tubule cells through mineralocorticoid receptor. Biochim Biophys Acta. 2013;1833:2143-52 pubmed publisher
	Brem A, Morris D, Li X, Ge Y, SHAW S, Gong R. Adrenalectomy amplifies aldosterone induced injury in cardiovascular tissue: an effect attenuated by adrenally derived steroids. Steroids. 2013;78:347-55 pubmed publisher
	Ruhs S, Strätz N, Schlör K, Meinel S, Mildenberger S, Rabe S, et al. Modulation of transcriptional mineralocorticoid receptor activity by nitrosative stress. Free Radic Biol Med. 2012;53:1088-100 pubmed publisher
	Montero Pedrazuela A, Fernández Lamo I, Alieva M, Pereda Pérez I, Venero C, Guadaño Ferraz A. Adult-onset hypothyroidism enhances fear memory and upregulates mineralocorticoid and glucocorticoid receptors in the amygdala. PLoS ONE. 2011;6:e26582 pubmed publisher
	Prager E, Brielmaier J, Bergstrom H, McGuire J, Johnson L. Localization of mineralocorticoid receptors at mammalian synapses. PLoS ONE. 2010;5:e14344 pubmed publisher
	Proszkowiec Weglarz M, Porter T. Functional characterization of chicken glucocorticoid and mineralocorticoid receptors. Am J Physiol Regul Integr Comp Physiol. 2010;298:R1257-68 pubmed publisher
	Gomez Sanchez C, de Rodriguez A, Romero D, Estess J, Warden M, Gomez Sanchez M, et al. Development of a panel of monoclonal antibodies against the mineralocorticoid receptor. Endocrinology. 2006;147:1343-8 pubmed

product information

Internal ID :

3478

Name :

rMR1-18 1D5

Depositor Name :

Gomez-Sanchez, C.

Depositor Institution :

G.V. Montgomery VA Medical Center

Date Deposited :

10/2/07

Allow Hybridoma Distribution :

Yes

Cells Available (legacy) :

Yes

Antigen :

mineralocorticoid receptor

Antigen Species :

Rat

Host Species :

mouse

Isotype :

MIgG1, kappa light chain

Isotype for catalog (legacy) :

IgG1, kappa light chain

Positive Tested Species Reactivity :

Canine,Chicken,Human,Mouse,Rabbit,Rat

Species Tested (legacy) :

rat, mouse, dog, human and rabbit

Initial Publication Pubmed ID :

16293659

Collections :

Cell signaling,Human,Transcription factors

Search Keywords :

Gomez-Sanchez, C., mineralocorticoid receptor, Rat, MIgG1, kappa light chain, Rat/Mouse/Canine/Human/Rabbit/Chicken, Nr3c2, Mlr, MCR, AB_1157909, monoclonal, Cell signaling/Transcription factors/Nucleus/Human, Immunohistochemistry/Immunofluorescence/Western Blot/Immunoprecipitation/Chromatin Immunoprecipitation/ELISA

Antigen Molecular Weight :

Predicted: 107 kDa; Apparent: 107 kDa

Gene :

Nr3c2

Alternate Gene Name(s) :

Mlr, MCR

Uniprot ID :

P22199

Antibody Registry ID :

AB_1157909

Immunogen :

METKGYHSLPEGLDMERR+C (KLH)

Immunogen Sequence :

Partial protein

Clonality :

Monoclonal

Myeloma Strain :

SP2

Epitope Mapped :

Yes

Epitope Location or Sequence :

N-terminus A/B domain (aa 1-18)

Epitope Map PubMed ID :

16293659

Recommended Applications :

Chromatin Immunoprecipitation,ELISA,Immunofluorescence,Immunohistochemistry,Immunoprecipitation,Western Blot

Immunoblotting (legacy) :

Yes

Immunohistochemistry Pubmed IDs :

16293659 21179518 23684706 22039511

Immunofluorescence Pubmed IDs :

23684706 24139875 31373631

Western Blot Pubmed IDs :

16293659 27650495 24062694 21179518 20181832 25258178 23684706 23287650 24139875 31373631

Immunoprecipitation Pubmed IDs :

31373631

Chromatin Immunoprecipitation Pubmed IDs :

24062694

ELISA Pubmed IDs :

16293659 22749806 23821666

Additional Information :

Should recognize all MR isoforms. The sequence of the rMR 1–18 peptide is identical in the rat, human, and mouse.

DSHB Growth Medium :

Iscove's

References (legacy) :

Endocrinology 147:1343-1348.; Front. Physiol. 4, 1-6.

more info or order :

Developmental Studies Hybridoma Bank product webpage