scabrous protein, Drosophila | Developmental Studies Hybridoma Bank mAb sca1 product information

product summary

company name :

Developmental Studies Hybridoma Bank

product type :

antibody

product name :

scabrous protein, Drosophila

catalog :

mAb sca1

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

mAB sca1

reactivity :

fruit fly

application :

western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation

more info or order :

Developmental Studies Hybridoma Bank product webpage

citations: 15

Reference
Muñoz Soriano V, Santos D, Durupt F, Casani S, Paricio N. Scabrous overexpression in the eye affects R3/R4 cell fate specification and inhibits notch signaling. Dev Dyn. 2016;245:166-74 pubmed publisher
Giagtzoglou N, Li T, Yamamoto S, Bellen H. Drosophila EHBP1 regulates Scabrous secretion during Notch-mediated lateral inhibition. J Cell Sci. 2013;126:3686-96 pubmed publisher
Doroquez D, Orr Weaver T, Rebay I. Split ends antagonizes the Notch and potentiates the EGFR signaling pathways during Drosophila eye development. Mech Dev. 2007;124:792-806 pubmed
Lim J, Lee O, Hsu Y, Singh A, Choi K. Drosophila TRAP230/240 are essential coactivators for Atonal in retinal neurogenesis. Dev Biol. 2007;308:322-30 pubmed
Mok L, Qin T, Bardot B, LeComte M, Homayouni A, Ahimou F, et al. Delta activity independent of its activity as a ligand of Notch. BMC Dev Biol. 2005;5:6 pubmed
Rawlins E, Lovegrove B, Jarman A. Echinoid facilitates Notch pathway signalling during Drosophila neurogenesis through functional interaction with Delta. Development. 2003;130:6475-84 pubmed
Rawlins E, White N, Jarman A. Echinoid limits R8 photoreceptor specification by inhibiting inappropriate EGF receptor signalling within R8 equivalence groups. Development. 2003;130:3715-24 pubmed
Hu Y, Fortini M. Different cofactor activities in gamma-secretase assembly: evidence for a nicastrin-Aph-1 subcomplex. J Cell Biol. 2003;161:685-90 pubmed
Chou Y, Chien C. Scabrous controls ommatidial rotation in the Drosophila compound eye. Dev Cell. 2002;3:839-50 pubmed
Hu Y, Ye Y, Fortini M. Nicastrin is required for gamma-secretase cleavage of the Drosophila Notch receptor. Dev Cell. 2002;2:69-78 pubmed
Baonza A, Casci T, Freeman M. A primary role for the epidermal growth factor receptor in ommatidial spacing in the Drosophila eye. Curr Biol. 2001;11:396-404 pubmed
Ye Y, Lukinova N, Fortini M. Neurogenic phenotypes and altered Notch processing in Drosophila Presenilin mutants. Nature. 1999;398:525-9 pubmed
Kr mer H, Phistry M. Genetic analysis of hook, a gene required for endocytic trafficking in drosophila. Genetics. 1999;151:675-84 pubmed
Lee E, Yu S, Hu X, Mlodzik M, Baker N. Functional analysis of the fibrinogen-related scabrous gene from Drosophila melanogaster identifies potential effector and stimulatory protein domains. Genetics. 1998;150:663-73 pubmed
Lee E, Hu X, Yu S, Baker N. The scabrous gene encodes a secreted glycoprotein dimer and regulates proneural development in Drosophila eyes. Mol Cell Biol. 1996;16:1179-88 pubmed

product information

Internal ID :

543

Name :

mAB sca1

Depositor Name :

Baker, N.

Depositor Institution :

Albert Einstein College of Medicine

Date Deposited :

8/30/95

Allow Hybridoma Distribution :

Yes

Cells Available (legacy) :

Yes

Antigen :

scabrous protein, Drosophila

Antigen Species :

Drosophila

Host Species :

mouse

Isotype :

MIgG1, kappa light chain

Isotype for catalog (legacy) :

IgG1, kappa light chain

Positive Tested Species Reactivity :

Drosophila

Species Tested (legacy) :

Drosophila

Initial Publication Pubmed ID :

8622662

Depositor Notes (Special Instructions) :

Monospecific in immunohistology or immunoblotting

Collections :

Cell signaling,Drosophila antigens

Search Keywords :

Baker, N., scabrous protein, Drosophila, Drosophila, MIgG1, kappa light chain, Drosophila, sca, CG17579,, AB_528459, monoclonal, Drosophila antigens/Cell signaling, Immunohistochemistry/Immunofluorescence/Western Blot/Immunoprecipitation

Antigen Molecular Weight :

Predicted: 90 kDa; Apparent: 300 kDa

Gene :

sca

Alternate Gene Name(s) :

CG17579,

Uniprot ID :

P21520

Antibody Registry ID :

AB_528459

Immunogen :

Recombinant sca-GST fusion protein

Immunogen Sequence :

Full length protein

Clonality :

Monoclonal

Myeloma Strain :

P3X63-Ag8.653

Epitope Mapped :

Yes

Epitope Location or Sequence :

aa 41-275

Epitope Map PubMed ID :

8622662

Recommended Applications :

Immunofluorescence,Immunohistochemistry,Immunoprecipitation,Western Blot

Immunoblotting (legacy) :

Yes

Immunohistochemistry Pubmed IDs :

11782315 9755198

Immunofluorescence Pubmed IDs :

10206647 26505171 11301250 17588724 12835388 12479809 9927460 14627723 17585897 23788431

Western Blot Pubmed IDs :

8622662

Immunoprecipitation Pubmed IDs :

8622662 15760463

DSHB Growth Medium :

Iscove's

References (legacy) :

Mol. Cell. Biol. 16, 1179-1188.

more info or order :

Developmental Studies Hybridoma Bank product webpage