product summary
company name :
Developmental Studies Hybridoma Bank
product type :
antibody
product name :
Sex combs reduced homeotic protein
catalog :
anti-Scr 6H4.1
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
anti-Scr 6H4.1
reactivity :
fruit fly
application :
western blot, immunohistochemistry, immunocytochemistry
citations: 17
Reference
Ortega Yáñez A, Cruz Ruiz S, Vázquez M, Zurita M. Different transcriptional responses by the CRISPRa system in distinct types of heterochromatin in Drosophila melanogaster. Sci Rep. 2022;12:11702 pubmed publisher
Zhu J, Ordway A, Weber L, Buddika K, Kumar J. Polycomb group (PcG) proteins and Pax6 cooperate to inhibit in vivo reprogramming of the developing Drosophila eye. Development. 2018;145: pubmed publisher
Urbach R, Jussen D, Technau G. Gene expression profiles uncover individual identities of gnathal neuroblasts and serial homologies in the embryonic CNS of Drosophila. Development. 2016;143:1290-301 pubmed publisher
Percival Smith A, Sivanantharajah L, Pelling J, Teft W. Developmental competence and the induction of ectopic proboscises in Drosophila melanogaster. Dev Genes Evol. 2013;223:375-387 pubmed
Devi T, Shyamala B. Male- and female-specific variants of doublesex gene products have different roles to play towards regulation of Sex combs reduced expression and sex comb morphogenesis in Drosophila. J Biosci. 2013;38:455-60 pubmed
Devi T, Amruthavalli C, Shyamala B. Evolution of sex comb from the primitive bristle pattern in Drosophila is associated with modification in the developmental regulatory protein Dachshund. Genesis. 2013;51:97-109 pubmed publisher
Lemons D, Pare A, McGinnis W. Three Drosophila Hox complex microRNAs do not have major effects on expression of evolutionarily conserved Hox gene targets during embryogenesis. PLoS ONE. 2012;7:e31365 pubmed publisher
Tanaka K, Barmina O, Sanders L, Arbeitman M, Kopp A. Evolution of sex-specific traits through changes in HOX-dependent doublesex expression. PLoS Biol. 2011;9:e1001131 pubmed publisher
Bhatia S, Pawar H, Dasari V, Mishra R, Chandrashekaran S, Brahmachari V. Chromatin remodeling protein INO80 has a role in regulation of homeotic gene expression in Drosophila. Genes Cells. 2010;15:725-35 pubmed publisher
ROBINETT C, Vaughan A, Knapp J, Baker B. Sex and the single cell. II. There is a time and place for sex. PLoS Biol. 2010;8:e1000365 pubmed publisher
Sivanantharajah L, Percival Smith A. Analysis of the sequence and phenotype of Drosophila Sex combs reduced alleles reveals potential functions of conserved protein motifs of the Sex combs reduced protein. Genetics. 2009;182:191-203 pubmed publisher
Diop S, Bertaux K, Vasanthi D, Sarkeshik A, Goirand B, Aragnol D, et al. Reptin and Pontin function antagonistically with PcG and TrxG complexes to mediate Hox gene control. EMBO Rep. 2008;9:260-6 pubmed publisher
Dos Santos N, Rubin T, Chalvet F, Gandille P, Cremazy F, Leroy J, et al. Drosophila retinal pigment cell death is regulated in a position-dependent manner by a cell memory gene. Int J Dev Biol. 2008;52:21-31 pubmed
Barmina O, Kopp A. Sex-specific expression of a HOX gene associated with rapid morphological evolution. Dev Biol. 2007;311:277-86 pubmed
Qi D, Jin H, Lilja T, Mannervik M. Drosophila Reptin and other TIP60 complex components promote generation of silent chromatin. Genetics. 2006;174:241-51 pubmed
Wang J, Lee C, Lin S, Lee T. Steroid hormone-dependent transformation of polyhomeotic mutant neurons in the Drosophila brain. Development. 2006;133:1231-40 pubmed
Glicksman M, Brower D. Expression of the Sex combs reduced protein in Drosophila larvae. Dev Biol. 1988;127:113-8 pubmed
product information
Internal ID :
1364
Name :
anti-Scr 6H4.1
Depositor Name :
Brower, D.
Depositor Institution :
University of Arizona
Date Deposited :
7/17/02
Allow Hybridoma Distribution :
Yes
Cells Available (legacy) :
Yes
Antigen :
Sex combs reduced homeotic protein
Antigen Species :
Drosophila
Host Species :
mouse
Isotype :
MIgG1
Isotype for catalog (legacy) :
IgG
Positive Tested Species Reactivity :
Drosophila
Species Tested (legacy) :
Drosophila
Initial Publication Pubmed ID :
2896135
Depositor Notes (Special Instructions) :
The depositor indicates this antibody works for immunprecipitation applications.
Collections :
Drosophila antigens,Neurodevelopment,Nucleus,Transcription factors
Search Keywords :
Brower, Danny, Sex combs reduced homeotic protein, Drosophila, MIgG1, Drosophila, Scr, CG1030; Dmel CG1030; DmScr; SCR, AB_528462, monoclonal
Antigen Molecular Weight :
Predicted: 44-kDa; Appparent: 54-58kDa
Gene :
Scr
Alternate Gene Name(s) :
CG1030; Dmel CG1030; DmScr; SCR
Uniprot ID :
P09077
Antibody Registry ID :
AB_528462
Synonyms (Alternate Clone Names) :
anti-Scr
Immunogen :
Recombinant LacZ-Scr Protein fragment
Immunogen Sequence :
a. a. 80-417
Clonality :
Monoclonal
Myeloma Strain :
NSO
Epitope Mapped :
Yes
Epitope Location or Sequence :
a.a. 80-131 (including a.a. 114-117)
Epitope Map PubMed ID :
2896135 19293143
Recommended Applications :
Immunofluorescence,Immunohistochemistry,Western Blot
Immunoblotting (legacy) :
+
Immunohistochemistry Pubmed IDs :
23938378 23197370 16816423 17868668
Immunofluorescence Pubmed IDs :
2896135 18259215 20545766 21886483 22393361 20454565 29530880 27095493
Western Blot Pubmed IDs :
2896135 24121940 19293143
Pubmed IDs :
18033669 16495309
Depositor Growth Medium :
Iscove's+AT27
DSHB Growth Medium :
RPMI
References (legacy) :
Dev. Biol. 127, 113-118.
company information
Developmental Studies Hybridoma Bank
University of Iowa
http://dshb.biology.uiowa.edu
headquarters: US