product summary
company name :
Developmental Studies Hybridoma Bank
product type :
antibody
product name :
Tyrosine hydroxylase (Tyrosine 3-monooxygenase)
catalog :
aTH
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
aTH
reactivity :
Japanese quail
application :
western blot, immunohistochemistry, immunocytochemistry
citations: 12
Reference
Todd L, Suarez L, Squires N, Zelinka C, Gribbins K, Fischer A. Comparative analysis of glucagonergic cells, glia, and the circumferential marginal zone in the reptilian retina. J Comp Neurol. 2016;524:74-89 pubmed publisher
Liang H, Fekete D, Andrisani O. CtBP2 downregulation during neural crest specification induces expression of Mitf and REST, resulting in melanocyte differentiation and sympathoadrenal lineage suppression. Mol Cell Biol. 2011;31:955-70 pubmed publisher
Bejarano Escobar R, Blasco M, DeGrip W, Oyola Velasco J, Martin Partido G, Francisco Morcillo J. Eye development and retinal differentiation in an altricial fish species, the senegalese sole (Solea senegalensis, Kaup 1858). J Exp Zool B Mol Dev Evol. 2010;314:580-605 pubmed publisher
Baratte S, Bonnaud L. Evidence of early nervous differentiation and early catecholaminergic sensory system during Sepia officinalis embryogenesis. J Comp Neurol. 2009;517:539-49 pubmed publisher
Bejarano Escobar R, Blasco M, DeGrip W, Martin Partido G, Francisco Morcillo J. Cell differentiation in the retina of an epibenthonic teleost, the Tench (Tinca tinca, Linneo 1758). Exp Eye Res. 2009;89:398-415 pubmed publisher
Lacosta A, Muniesa P, Ruberte J, Sarasa M, Dominguez L. Novel expression patterns of Pax3/Pax7 in early trunk neural crest and its melanocyte and non-melanocyte lineages in amniote embryos. Pigment Cell Res. 2005;18:243-51 pubmed
Lee V, Bronner Fraser M, Baker C. Restricted response of mesencephalic neural crest to sympathetic differentiation signals in the trunk. Dev Biol. 2005;278:175-92 pubmed
Ziller C, Mirabel M, Vandenbunder B, Fauquet M. The tyrosine hydroxylase gene is expressed in endoderm and pancreas of early quail embryos. Anat Embryol (Berl). 1994;189:307-15 pubmed
Selleck M, Bronner Fraser M. Origins of the avian neural crest: the role of neural plate-epidermal interactions. Development. 1995;121:525-38 pubmed
Fauquet M, Ziller C. A monoclonal antibody directed against quail tyrosine hydroxylase: description and use in immunocytochemical studies on differentiating neural crest cells. J Histochem Cytochem. 1989;37:1197-205 pubmed
Garcia Arraras J, Lugo Chinchilla A, Chévere Colón I. The expression of neuropeptide Y immunoreactivity in the avian sympathoadrenal system conforms with two models of coexpression development for neurons and chromaffin cells. Development. 1992;115:617-27 pubmed
Nataf V, Monier S. Effect of insulin and insulin-like growth factor I on the expression of the catecholaminergic phenotype by neural crest cells. Brain Res Dev Brain Res. 1992;69:59-66 pubmed
product information
Internal ID :
2964
Name :
aTH
Depositor Name :
Le Douarin, N. / Ziller, C.
Depositor Institution :
Institut d’Embryologie Cellulaire et Moleculaire du C.N.R.S. et du College de France, Nogent sur Marne
Date Deposited :
8/13/92
Allow Hybridoma Distribution :
Yes
Cells Available (legacy) :
Yes
Antigen :
Tyrosine hydroxylase (Tyrosine 3-monooxygenase)
Antigen Species :
Quail
Host Species :
mouse
Isotype :
MIgG2a
Isotype for catalog (legacy) :
IgG2a
Positive Tested Species Reactivity :
Chicken,Cuttlefish,Quail
Species Tested (legacy) :
chick & quail
Initial Publication Pubmed ID :
2569003
Depositor Notes (Special Instructions) :
This antibody gives an intracytoplasmic staining of dopaminergic neurons.
Collections :
Enzymes,Neurodevelopment
Search Keywords :
Le Douarin, N. / Ziller, C., Tyrosine hydroxylase (Tyrosine 3-monooxygenase), Quail, MIgG2a, Quail/Chicken/Cuttlefish, TH, , AB_528490, monoclonal, Enzymes/Neurodevelopment, Immunohistochemistry/Immunofluorescence/Western blot
Antigen Molecular Weight :
Predicted: 56 kDa; Apparent: 63 kDa
Gene :
TH
Uniprot ID :
P11982
Antibody Registry ID :
AB_528490
Synonyms (Alternate Clone Names) :
alphaQTOH
Immunogen :
Recombinant TH (aa 60-368)/beta galactosidase fusion protein
Immunogen Sequence :
Partial protein
Clonality :
Monoclonal
Myeloma Strain :
SP2/0
Epitope Mapped :
Yes
Epitope Location or Sequence :
aa 60-368
Epitope Map PubMed ID :
2569003
Recommended Applications :
Immunofluorescence,Immunohistochemistry,Western Blot
Immunohistochemistry Pubmed IDs :
2569003 19795495
Immunofluorescence Pubmed IDs :
2569003 15649470 21199918 7768190 7915502 1358479 1358595 26053997
Western Blot Pubmed IDs :
2569003 21199918 19795495
Pubmed IDs :
16029418
Additional Information :
This protein is involved in the synthesis of dopamine from L-tyrosine.
DSHB Growth Medium :
Iscove's
References (legacy) :
J. Histochem. Cytochem. 37, 1197-1205.; Development 121, 525-538.; Pigment Cell Res. 18(4), 243-251.
company information
Developmental Studies Hybridoma Bank
University of Iowa
http://dshb.biology.uiowa.edu
headquarters: US